Dayna Yong Wei Wei1, Merwyn Chew2,3, Charumathi Sabanayagam4,5. 1. Department of Ophthalmology, National University Hospital, National University Health System, Singapore, Singapore. 2. Department of Ophthalmology, JurongHealth, National University Health System, Singapore, Singapore. 3. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 4. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. charumathi.sabanayagam@seri.com.sg. 5. Ophthalmology and Visual Science Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. charumathi.sabanayagam@seri.com.sg.
Abstract
PURPOSE OF REVIEW: To summarise the association between obstructive sleep apnoea and diabetic retinopathy and diabetic macular oedema. To examine the effects of other sleep parameters on diabetic retinopathy and diabetic macular oedema. To discuss the pathophysiology of diabetic eye changes and how it is related to obstructive sleep apnoea. RECENT FINDINGS: Conflicting data exists in terms of the association of diabetic eye changes with sleep apnoea and/or other sleep parameters. Various cross-sectional studies show PDR to be associated with the prevalence of OSA. Patients who underwent continuous positive airway pressure (CPAP) treatment were significantly less likely to develop pre/proliferative DR. Secondary sleep parameters generally are not associated with DR except for long duration of sleep. Differences in reporting could be due to the different thresholds set to define OSA/ODI and severity of DR/DME, in addition to factors used in multivariate analysis. There is a need for further studies with long-term follow-up and to assess the impact of CPAP on the development and progression of diabetic eye change(s).
PURPOSE OF REVIEW: To summarise the association between obstructive sleep apnoea and diabetic retinopathy and diabetic macular oedema. To examine the effects of other sleep parameters on diabetic retinopathy and diabetic macular oedema. To discuss the pathophysiology of diabetic eye changes and how it is related to obstructive sleep apnoea. RECENT FINDINGS: Conflicting data exists in terms of the association of diabetic eye changes with sleep apnoea and/or other sleep parameters. Various cross-sectional studies show PDR to be associated with the prevalence of OSA. Patients who underwent continuous positive airway pressure (CPAP) treatment were significantly less likely to develop pre/proliferative DR. Secondary sleep parameters generally are not associated with DR except for long duration of sleep. Differences in reporting could be due to the different thresholds set to define OSA/ODI and severity of DR/DME, in addition to factors used in multivariate analysis. There is a need for further studies with long-term follow-up and to assess the impact of CPAP on the development and progression of diabetic eye change(s).
Authors: I M Stratton; E M Kohner; S J Aldington; R C Turner; R R Holman; S E Manley; D R Matthews Journal: Diabetologia Date: 2001-02 Impact factor: 10.122
Authors: Quratul A Altaf; Paul Dodson; Asad Ali; Neil T Raymond; Helen Wharton; Hannah Fellows; Rachel Hampshire-Bancroft; Mirriam Shah; Emma Shepherd; Jamili Miah; Anthony H Barnett; Abd A Tahrani Journal: Am J Respir Crit Care Med Date: 2017-10-01 Impact factor: 21.405