Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Polyketide-chain branching by an enzymatic Michael addition.

Literature DB >> 19266509

Polyketide-chain branching by an enzymatic Michael addition.

Björn Kusebauch¹, Benjamin Busch, Kirstin Scherlach, Martin Roth, Christian Hertweck.

Abstract

A new "branch" for polyketide synthases was discovered in the biosynthesis of the antimitotic rhizoxin complex in the endofungal bacterium Burkholderia rhizoxinica. Genetic engineering and the structural elucidation of pathway intermediates revealed that a complex polyketide chain is branched at the beta position by an unprecedented conjugate addition of an acetyl building block to an acryloyl precursor (see scheme).

Entities: Chemical Species

Mesh：

Substances：

Year: 2009 PMID： 19266509 DOI： 10.1002/anie.200900277

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

Keyword Cloud
Cited

15 in total

1. Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.

Authors: Jeremy R Lohman; Ming Ma; Jerzy Osipiuk; Boguslaw Nocek; Youngchang Kim; Changsoo Chang; Marianne Cuff; Jamey Mack; Lance Bigelow; Hui Li; Michael Endres; Gyorgy Babnigg; Andrzej Joachimiak; George N Phillips; Ben Shen
Journal: Proc Natl Acad Sci U S A Date: 2015-09-29 Impact factor: 11.205

2. Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching.

Authors: Srividhya Sundaram; Daniel Heine; Christian Hertweck
Journal: Nat Chem Biol Date: 2015-10-19 Impact factor: 15.040

3. Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase.

Authors: Tonia J Buchholz; Christopher M Rath; Nicole B Lopanik; Noah P Gardner; Kristina Håkansson; David H Sherman
Journal: Chem Biol Date: 2010-10-29

4. Polyketide proofreading by an acyltransferase-like enzyme.

Authors: Katja Jensen; Holger Niederkrüger; Katrin Zimmermann; Anna L Vagstad; Jana Moldenhauer; Nicole Brendel; Sarah Frank; Petra Pöplau; Christoph Kohlhaas; Craig A Townsend; Marco Oldiges; Christian Hertweck; Jörn Piel
Journal: Chem Biol Date: 2012-03-23

10. Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.

Authors: Jeremy R Lohman; Sheng-Xiong Huang; Geoffrey P Horsman; Paul E Dilfer; Tingting Huang; Yihua Chen; Evelyn Wendt-Pienkowski; Ben Shen
Journal: Mol Biosyst Date: 2013-01-29

Polyketide-chain branching by an enzymatic Michael addition.

1. Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.

2. Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching.

3. Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthase.

4. Polyketide proofreading by an acyltransferase-like enzyme.

5. Burkholderia as a Source of Natural Products.

Review 6. The Enzymology of Organic Transformations: A Survey of Name Reactions in Biological Systems.

7. Bacterial symbionts and natural products.

8. Natural products version 2.0: connecting genes to molecules.

9. Vinylogous chain branching catalysed by a dedicated polyketide synthase module.

10. Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.