Literature DB >> 26479442

Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching.

Srividhya Sundaram1, Daniel Heine1, Christian Hertweck1,2.   

Abstract

Biosynthesis of rhizoxin in Burkholderia rhizoxinica affords an unusual polyketide synthase module with ketosynthase and branching domains that install the δ-lactone, conferring antimitotic activity. To investigate their functions in chain branching, we designed chimeric modules with structurally similar domains from a glutarimide-forming module and a dehydratase. Biochemical, kinetic and mutational analyses reveal a structural role of the accessory domains and multifarious catalytic actions of the ketosynthase.

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Year:  2015        PMID： 26479442     DOI： 10.1038/nchembio.1932

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  27 in total

1.  A gene cluster encoding rhizoxin biosynthesis in "Burkholderia rhizoxina", the bacterial endosymbiont of the fungus Rhizopus microsporus.

Authors:  Laila P Partida-Martinez; Christian Hertweck
Journal:  Chembiochem       Date:  2007-01-02       Impact factor: 3.164

2.  Protein structure prediction on the Web: a case study using the Phyre server.

Authors:  Lawrence A Kelley; Michael J E Sternberg
Journal:  Nat Protoc       Date:  2009       Impact factor: 13.491

3.  Twofold polyketide branching by a stereoselective enzymatic Michael addition.

Authors:  Daniel Heine; Srividhya Sundaram; Tom Bretschneider; Christian Hertweck
Journal:  Chem Commun (Camb)       Date:  2015-06-18       Impact factor: 6.222

4.  Formation of 1,3-cyclohexanediones and resorcinols catalyzed by a widely occurring ketosynthase.

Authors:  Sebastian W Fuchs; Kenan A J Bozhüyük; Darko Kresovic; Florian Grundmann; Veronica Dill; Alexander O Brachmann; Nicholas R Waterfield; Helge B Bode
Journal:  Angew Chem Int Ed Engl       Date:  2013-02-19       Impact factor: 15.336

5.  Biosynthetic code for divergolide assembly in a bacterial mangrove endophyte.

Authors:  Zhongli Xu; Martin Baunach; Ling Ding; Huiyun Peng; Jakob Franke; Christian Hertweck
Journal:  Chembiochem       Date:  2014-05-27       Impact factor: 3.164

6.  Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex.

Authors:  Shi Chen; Xi Huang; Xiufen Zhou; Linquan Bai; Jing He; Ki Jun Jeong; Sang Yup Lee; Zixin Deng
Journal:  Chem Biol       Date:  2003-11

Review 7.  Isoprenoid-like alkylations in polyketide biosynthesis.

Authors:  Christopher T Calderone
Journal:  Nat Prod Rep       Date:  2008-06-18       Impact factor: 13.423

8.  iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.

Authors:  Si-Kyu Lim; Jianhua Ju; Emmanuel Zazopoulos; Hui Jiang; Jeong-Woo Seo; Yihua Chen; Zhiyang Feng; Scott R Rajski; Chris M Farnet; Ben Shen
Journal:  J Biol Chem       Date:  2009-09-02       Impact factor: 5.157

9.  Structural basis of head to head polyketide fusion by CorB.

Authors:  Georg Zocher; Joachim Vilstrup; Daniel Heine; Asis Hallab; Emilie Goralski; Christian Hertweck; Mark Stahl; Till F Schäberle; Thilo Stehle
Journal:  Chem Sci       Date:  2015-08-06       Impact factor: 9.825

10.  Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by pseudomonas fluorescens: pseudomonic acid B biosynthesis precedes pseudomonic acid A.

Authors:  Joanne Hothersall; Ji'en Wu; Ayesha S Rahman; Jennifer A Shields; James Haddock; Nicola Johnson; Sian M Cooper; Elton R Stephens; Russell J Cox; John Crosby; Christine L Willis; Thomas J Simpson; Christopher M Thomas
Journal:  J Biol Chem       Date:  2007-03-23       Impact factor: 5.157
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  6 in total

1.  Burkholderia as a Source of Natural Products.

Authors:  Sylvia Kunakom; Alessandra S Eustáquio
Journal:  J Nat Prod       Date:  2019-07-11       Impact factor: 4.050

2.  The hidden enzymology of bacterial natural product biosynthesis.

Authors:  Thomas A Scott; Jörn Piel
Journal:  Nat Rev Chem       Date:  2019-06-12       Impact factor: 34.035

Review 3.  Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides.

Authors:  Franziska Hemmerling; Frank Hahn
Journal:  Beilstein J Org Chem       Date:  2016-07-20       Impact factor: 2.883

Review 4.  Recent Advances in Understanding and Engineering Polyketide Synthesis.

Authors:  Wenjun Zhang; Joyce Liu
Journal:  F1000Res       Date:  2016-02-23

5.  Automated structure prediction of trans-acyltransferase polyketide synthase products.

Authors:  Eric J N Helfrich; Reiko Ueoka; Alon Dolev; Michael Rust; Roy A Meoded; Agneya Bhushan; Gianmaria Califano; Rodrigo Costa; Muriel Gugger; Christoph Steinbeck; Pablo Moreno; Jörn Piel
Journal:  Nat Chem Biol       Date:  2019-07-15       Impact factor: 15.040

Review 6.  Application of metabolic engineering to enhance the content of alkaloids in medicinal plants.

Authors:  Soledad Mora-Vásquez; Guillermo Gael Wells-Abascal; Claudia Espinosa-Leal; Guy A Cardineau; Silverio García-Lara
Journal:  Metab Eng Commun       Date:  2022-02-16
  6 in total

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