Literature DB >> 19257559

Viscoelasticity in homogeneous protein solutions.

Weichun Pan1, Luis Filobelo, Ngoc D Q Pham, Oleg Galkin, Veselina V Uzunova, Peter G Vekilov.   

Abstract

We probe the transport properties in protein solutions stable with respect to any, solid or liquid, phase separation as a step in the understanding of transport in the cytosol of live cells. We determine the mean-squared displacement of probe particles in the time range 10;{-3}-10 s in solutions of a model protein. The tested solutions exhibit significant elasticity at high frequencies, while at low frequencies, they are purely viscous. We attribute this viscoelasticity to a dense network of weakly-bound chains of protein molecules with characteristic lifetime of 10-100 ms. The found intrinsic viscoelasticity of protein solutions should be considered in biochemical kinetics models.

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Year:  2009        PMID: 19257559     DOI: 10.1103/PhysRevLett.102.058101

Source DB:  PubMed          Journal:  Phys Rev Lett        ISSN: 0031-9007            Impact factor:   9.161


  13 in total

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Journal:  Biophys J       Date:  2010-04-07       Impact factor: 4.033

2.  Aging and nonergodicity beyond the Khinchin theorem.

Authors:  S Burov; R Metzler; E Barkai
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-12       Impact factor: 11.205

Review 3.  Nucleation precursors in protein crystallization.

Authors:  Peter G Vekilov; Maria A Vorontsova
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-02-20       Impact factor: 1.056

4.  Nucleation.

Authors:  Peter G Vekilov
Journal:  Cryst Growth Des       Date:  2010-11-15       Impact factor: 4.076

5.  Transient anomalous subdiffusion: effects of specific and nonspecific probe binding with actin gels.

Authors:  Hugo Sanabria; M Neal Waxham
Journal:  J Phys Chem B       Date:  2010-01-21       Impact factor: 2.991

6.  Bacterial chromosomal loci move subdiffusively through a viscoelastic cytoplasm.

Authors:  Stephanie C Weber; Andrew J Spakowitz; Julie A Theriot
Journal:  Phys Rev Lett       Date:  2010-06-08       Impact factor: 9.161

7.  Supramolecular Structures of Enzyme Clusters.

Authors:  Nadeem Javid; Karsten Vogtt; Sangita Roy; Andrew R Hirst; Armin Hoell; Ian W Hamley; Rein V Ulijn; Jan Sefcik
Journal:  J Phys Chem Lett       Date:  2011-05-18       Impact factor: 6.475

8.  Cooperative self-assembly of peptide gelators and proteins.

Authors:  Nadeem Javid; Sangita Roy; Mischa Zelzer; Zhimou Yang; Jan Sefcik; Rein V Ulijn
Journal:  Biomacromolecules       Date:  2013-11-27       Impact factor: 6.988

9.  Superdiffusion dominates intracellular particle motion in the supercrowded cytoplasm of pathogenic Acanthamoeba castellanii.

Authors:  Julia F Reverey; Jae-Hyung Jeon; Han Bao; Matthias Leippe; Ralf Metzler; Christine Selhuber-Unkel
Journal:  Sci Rep       Date:  2015-06-30       Impact factor: 4.379

10.  Underdamped scaled Brownian motion: (non-)existence of the overdamped limit in anomalous diffusion.

Authors:  Anna S Bodrova; Aleksei V Chechkin; Andrey G Cherstvy; Hadiseh Safdari; Igor M Sokolov; Ralf Metzler
Journal:  Sci Rep       Date:  2016-07-27       Impact factor: 4.379

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