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Literature DB >> 19253320

Ratiometric single-nanoparticle oxygen sensors for biological imaging.

Changfeng Wu¹, Barbara Bull, Kenneth Christensen, Jason McNeill.

Abstract

It makes sense: Conjugated polymer nanoparticles doped with a platinum porphyrin dye exhibit bright phosphorescence that is highly sensitive to the concentration of molecular oxygen. The small size, extraordinary brightness, excellent sensitivity, and ratiometric emission, together with the demonstration of single-particle sensing and cellular uptake, indicate the potential of the nanoparticle sensors for quantitative mapping of local molecular oxygen concentration.

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Year: 2009 PMID： 19253320 PMCID： PMC2753190 DOI： 10.1002/anie.200805894

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

26 in total

1. Single-molecule triplet-state photon antibunching at room temperature.

Authors: Dehong Hu; H Peter Lu
Journal: J Phys Chem B Date: 2005-05-26 Impact factor: 2.991

2. Preparation and encapsulation of highly fluorescent conjugated polymer nanoparticles.

Authors: Changfeng Wu; Craig Szymanski; Jason McNeill
Journal: Langmuir Date: 2006-03-28 Impact factor: 3.882

3. Development of a submicrometer optical fiber oxygen sensor.

Authors: Z Rosenzweig; R Kopelman
Journal: Anal Chem Date: 1995-08-01 Impact factor: 6.986

4. Imaging of phosphorescence: a novel method for measuring oxygen distribution in perfused tissue.

Authors: W L Rumsey; J M Vanderkooi; D F Wilson
Journal: Science Date: 1988-09-23 Impact factor: 47.728

5. A real-time ratiometric method for the determination of molecular oxygen inside living cells using sol-gel-based spherical optical nanosensors with applications to rat C6 glioma.

Authors: H Xu; J W Aylott; R Kopelman; T J Miller; M A Philbert
Journal: Anal Chem Date: 2001-09-01 Impact factor: 6.986

6. Direct observation of triplet state emission of single molecules: single molecule phosphorescence quenching of metalloporphyrin and organometallic complexes by molecular oxygen and their quenching rate distributions.

Authors: Erwen Mei; Sergei Vinogradov; Robin M Hochstrasser
Journal: J Am Chem Soc Date: 2003-10-29 Impact factor: 15.419

7. Noninvasive imaging of the distribution in oxygen in tissue in vivo using near-infrared phosphors.

Authors: S A Vinogradov; L W Lo; W T Jenkins; S M Evans; C Koch; D F Wilson
Journal: Biophys J Date: 1996-04 Impact factor: 4.033

8. Energy Transfer in a Nanoscale Multichromophoric System: Fluorescent Dye-Doped Conjugated Polymer Nanoparticles.

Authors: Changfeng Wu; Yueli Zheng; Craig Szymanski; Jason McNeill
Journal: J Phys Chem C Nanomater Interfaces Date: 2008-02-14 Impact factor: 4.126

9. Multicolor conjugated polymer dots for biological fluorescence imaging.

Authors: Changfeng Wu; Barbara Bull; Craig Szymanski; Kenneth Christensen; Jason McNeill
Journal: ACS Nano Date: 2008-11-25 Impact factor: 15.881

Review 10. Cellular oxygen sensing need in CNS function: physiological and pathological implications.

Authors: Till Acker; Helmut Acker
Journal: J Exp Biol Date: 2004-08 Impact factor: 3.312

45 in total

1. Bioconjugation of ultrabright semiconducting polymer dots for specific cellular targeting.

Authors: Changfeng Wu; Thomas Schneider; Maxwell Zeigler; Jiangbo Yu; Perry G Schiro; Daniel R Burnham; Jason D McNeill; Daniel T Chiu
Journal: J Am Chem Soc Date: 2010-11-03 Impact factor: 15.419

Review 2. The concept of λ-ratiometry in fluorescence sensing and imaging.

Authors: Alexander P Demchenko
Journal: J Fluoresc Date: 2010-04-01 Impact factor: 2.217

3. Mechanism of cellular uptake of highly fluorescent conjugated polymer nanoparticles.

Authors: Lawrence P Fernando; Prakash K Kandel; Jiangbo Yu; Jason McNeill; P Christine Ackroyd; Kenneth A Christensen
Journal: Biomacromolecules Date: 2010-10-11 Impact factor: 6.988

4. Water-soluble porphyrin nanospheres: enhanced photo-physical properties achieved via cyclodextrin driven double self-inclusion.

Authors: Hong Zhang; Boyu Zhang; Mengyuan Zhu; Scott M Grayson; Russell Schmehl; Janarthanan Jayawickramarajah
Journal: Chem Commun (Camb) Date: 2014-05-14 Impact factor: 6.222