OBJECTIVE: To evaluate the association of radiotherapy to subsequent second cancers in endometrial carcinoma survivors. METHODS: Subjects with endometrial cancer as their first malignancy were identified from the Surveillance, Epidemiology and End Results (SEER) database from 1973 to 2004 and were divided into radiation (R) and No Radiation (NR) groups. Person years at risk (PYR), observed (O) and expected (E) counts and SIR (standardized incidence ratio) were determined. (%) increase in relative risk (RR) for R vs. NR group was calculated using Poisson regression. Absolute Excess Risk (AER) was 'O' minus 'E' per 10,000 PYRs. RESULTS: Of 90,502 subjects 31,643 (34.9%) were in R and 52,182 (57.6%) in NR. The radiation status of 6677 (7.3%) was unknown. In the R group 4203 developed second cancers vs. 5563 in NR group; relative risk for R group-1.25 (95% CI 1.20 to 1.29). A total of 17.11 excess tumors were observed in R group (AER). The relative risk increased with latency of exposure and peaked at (>10 years), being 40% (p<0.001). The statistically significant (%) increase in RR for individual organs was as follows: urinary bladder (124%), vagina (88%), vulva (83%), sarcoma (70%), colon and rectum (43%) and lung (29%). CONCLUSION: In the largest study reporting on association of radiotherapy to subsequent second neoplasms in endometrial cancer survivors, the increased risk of second cancers was most pronounced in the field of exposure and was affected by latency since exposure.
OBJECTIVE: To evaluate the association of radiotherapy to subsequent second cancers in endometrial carcinoma survivors. METHODS: Subjects with endometrial cancer as their first malignancy were identified from the Surveillance, Epidemiology and End Results (SEER) database from 1973 to 2004 and were divided into radiation (R) and No Radiation (NR) groups. Person years at risk (PYR), observed (O) and expected (E) counts and SIR (standardized incidence ratio) were determined. (%) increase in relative risk (RR) for R vs. NR group was calculated using Poisson regression. Absolute Excess Risk (AER) was 'O' minus 'E' per 10,000 PYRs. RESULTS: Of 90,502 subjects 31,643 (34.9%) were in R and 52,182 (57.6%) in NR. The radiation status of 6677 (7.3%) was unknown. In the R group 4203 developed second cancers vs. 5563 in NR group; relative risk for R group-1.25 (95% CI 1.20 to 1.29). A total of 17.11 excess tumors were observed in R group (AER). The relative risk increased with latency of exposure and peaked at (>10 years), being 40% (p<0.001). The statistically significant (%) increase in RR for individual organs was as follows: urinary bladder (124%), vagina (88%), vulva (83%), sarcoma (70%), colon and rectum (43%) and lung (29%). CONCLUSION: In the largest study reporting on association of radiotherapy to subsequent second neoplasms in endometrial cancer survivors, the increased risk of second cancers was most pronounced in the field of exposure and was affected by latency since exposure.
Authors: Stefan Lönn; Ethel S Gilbert; Elaine Ron; Susan A Smith; Marilyn Stovall; Rochelle E Curtis Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-02 Impact factor: 4.254
Authors: Tracy Spinks; Heidi W Albright; Thomas W Feeley; Ron Walters; Thomas W Burke; Thomas Aloia; Eduardo Bruera; Aman Buzdar; Lewis Foxhall; David Hui; Barbara Summers; Alma Rodriguez; Raymond Dubois; Kenneth I Shine Journal: Cancer Date: 2011-11-01 Impact factor: 6.860
Authors: Mallory G Cases; Andrew D Frugé; Jennifer F De Los Santos; Julie L Locher; Alan B Cantor; Kerry P Smith; Tony A Glover; Harvey J Cohen; Michael Daniel; Casey D Morrow; Douglas R Moellering; Wendy Demark-Wahnefried Journal: Contemp Clin Trials Date: 2016-08-23 Impact factor: 2.226
Authors: Matthew M Harkenrider; Alec M Block; Kaled M Alektiar; David K Gaffney; Ellen Jones; Ann Klopp; Akila N Viswanathan; William Small Journal: Brachytherapy Date: 2016-05-31 Impact factor: 2.362
Authors: Rafael Samper-Ternent; Humera Asem; Dong D Zhang; Yong-Fang Kuo; Sandra S Hatch; Jean L Freeman; Abbey B Berenson Journal: J Geriatr Oncol Date: 2012-07-18 Impact factor: 3.599