OBJECTIVE: To test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer of embryos with a normal chromosomal pattern for the chromosomes studied with preimplantation genetic screening (PGS) compared with patients who had an embryo transfer without PGS. DESIGN: Prospective randomized controlled trial (RCT). SETTING: Academic tertiary setting. PATIENT(S): Patients with AMA (> or =35 years). INTERVENTION(S): In an RCT, the clinical IR per embryo transferred was compared after embryo transfer on day 5 or 6 between the PGS group (analysis of chromosomes 13, 16, 18, 21, 22, X, and Y) and the Control group without PGS. MAIN OUTCOME MEASURE(S): No differences were observed between the PGS group and the Control group for the clinical IR (15.1%; 14.9%; rate ratio 1.01; exact confidence interval [CI], 0.25-5.27), the ongoing IR (at 12 weeks) (9.4%; 14.9%), and the live born rate per embryo transferred (9.4%; 14.9%; rate ratio 0.63; exact CI, 0.08-3.37). Fewer embryos were transferred in the PGS group (1.6 +/- 0.6) than in the Control group (2.0 +/- 0.6). A normal diploid status was observed in 30.3% of the embryos screened by PGS. CONCLUSION(S): In this RCT, the results did not confirm the hypothesis that PGS results in improved reproductive outcome in patients with AMA. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
RCT Entities:
OBJECTIVE: To test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer of embryos with a normal chromosomal pattern for the chromosomes studied with preimplantation genetic screening (PGS) compared with patients who had an embryo transfer without PGS. DESIGN: Prospective randomized controlled trial (RCT). SETTING: Academic tertiary setting. PATIENT(S): Patients with AMA (> or =35 years). INTERVENTION(S): In an RCT, the clinical IR per embryo transferred was compared after embryo transfer on day 5 or 6 between the PGS group (analysis of chromosomes 13, 16, 18, 21, 22, X, and Y) and the Control group without PGS. MAIN OUTCOME MEASURE(S): No differences were observed between the PGS group and the Control group for the clinical IR (15.1%; 14.9%; rate ratio 1.01; exact confidence interval [CI], 0.25-5.27), the ongoing IR (at 12 weeks) (9.4%; 14.9%), and the live born rate per embryo transferred (9.4%; 14.9%; rate ratio 0.63; exact CI, 0.08-3.37). Fewer embryos were transferred in the PGS group (1.6 +/- 0.6) than in the Control group (2.0 +/- 0.6). A normal diploid status was observed in 30.3% of the embryos screened by PGS. CONCLUSION(S): In this RCT, the results did not confirm the hypothesis that PGS results in improved reproductive outcome in patients with AMA. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Authors: Sandra Zamora; Ana Clavero; M Carmen Gonzalvo; Juan de Dios Luna Del Castillo; Jose Antonio Roldán-Nofuentes; Juan Mozas; Jose Antonio Castilla Journal: J Assist Reprod Genet Date: 2011-06-29 Impact factor: 3.412
Authors: D S Johnson; G Gemelos; J Baner; A Ryan; C Cinnioglu; M Banjevic; R Ross; M Alper; B Barrett; J Frederick; D Potter; B Behr; M Rabinowitz Journal: Hum Reprod Date: 2010-01-24 Impact factor: 6.918