OBJECTIVE: Cancer patients are at a relatively high risk of venous thromboembolism (VTE), and this has implications for surgical outcome. DATA SOURCE: English literature search including the keywords cancer, surgery and VTE was undertaken to review the risk, etiology, prevention and treatment of VTE in surgical oncology patients. DATA SYNTHESIS: Malignant disease is highlighted as an important risk factor for VTE with an odds ratio of 6.5. The risk factors include higher age, previous VTE, advanced cancer, length of operation and immobility. CONCLUSIONS: Use of in-hospital thromboprophylaxis with low-molecular-weight heparin (LMWH) or low dose unfractionated heparin with graded stockings has been validated both in terms of safety and efficacy and should be considered for all patients. Subcutaneous LMWH has replaced unfractionated heparin for the initial treatment of VTE. The use of long-term LMWH instead of oral anticoagulants can substantially reduce the risk of recurrent VTE without increased bleeding. Recently, results of few trials have shown that LMWH may improve patient survival.
OBJECTIVE:Cancerpatients are at a relatively high risk of venous thromboembolism (VTE), and this has implications for surgical outcome. DATA SOURCE: English literature search including the keywords cancer, surgery and VTE was undertaken to review the risk, etiology, prevention and treatment of VTE in surgical oncology patients. DATA SYNTHESIS: Malignant disease is highlighted as an important risk factor for VTE with an odds ratio of 6.5. The risk factors include higher age, previous VTE, advanced cancer, length of operation and immobility. CONCLUSIONS: Use of in-hospital thromboprophylaxis with low-molecular-weight heparin (LMWH) or low dose unfractionated heparin with graded stockings has been validated both in terms of safety and efficacy and should be considered for all patients. Subcutaneous LMWH has replaced unfractionated heparin for the initial treatment of VTE. The use of long-term LMWH instead of oral anticoagulants can substantially reduce the risk of recurrent VTE without increased bleeding. Recently, results of few trials have shown that LMWH may improve patient survival.
Authors: Ashley Graul; Nawar Latif; Xiaochen Zhang; Lorraine T Dean; Mark Morgan; Robert Giuntoli; Robert Burger; Sarah Kim; Emily Ko Journal: Int J Gynecol Cancer Date: 2017-03 Impact factor: 3.437
Authors: Olivier Q Groot; Paul T Ogink; Stein J Janssen; Nuno Rui Paulino Pereira; Santiago Lozano-Calderon; Kevin Raskin; Francis Hornicek; Joseph H Schwab Journal: Clin Orthop Relat Res Date: 2018-10 Impact factor: 4.176
Authors: M Byrne; J V Reynolds; J S O'Donnell; M Keogan; B White; M Byrne; S Murphy; S G Maher; G P Pidgeon Journal: Br J Cancer Date: 2009-12-01 Impact factor: 7.640