Literature DB >> 19239889

Pre-mRNA processing reaches back to transcription and ahead to translation.

Melissa J Moore1, Nick J Proudfoot.   

Abstract

The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly interconnected. This review discusses how pre-mRNA processing, including 5' cap addition, splicing, and polyadenylation, contributes to both the efficiency and fidelity of gene expression. The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven.

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Year:  2009        PMID： 19239889     DOI： 10.1016/j.cell.2009.02.001

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  440 in total

Review 1.  Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expression.

Authors:  Carol S Lutz; Alexandra Moreira
Journal:  Wiley Interdiscip Rev RNA       Date:  2011 Jan-Feb       Impact factor: 9.957

2.  Export and stability of naturally intronless mRNAs require specific coding region sequences and the TREX mRNA export complex.

Authors:  Haixin Lei; Anusha P Dias; Robin Reed
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-18       Impact factor: 11.205

3.  TCERG1 regulates alternative splicing of the Bcl-x gene by modulating the rate of RNA polymerase II transcription.

Authors:  Marta Montes; Alexandre Cloutier; Noemí Sánchez-Hernández; Laetitia Michelle; Bruno Lemieux; Marco Blanchette; Cristina Hernández-Munain; Benoit Chabot; Carlos Suñé
Journal:  Mol Cell Biol       Date:  2011-12-12       Impact factor: 4.272

4.  Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II.

Authors:  Humaira Gowher; Kevin Brick; R Daniel Camerini-Otero; Gary Felsenfeld
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-30       Impact factor: 11.205

5.  The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex.

Authors:  Andrea Giovanni Murachelli; Judith Ebert; Claire Basquin; Hervé Le Hir; Elena Conti
Journal:  Nat Struct Mol Biol       Date:  2012-03-04       Impact factor: 15.369

6.  Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention.

Authors:  Karen Yap; Zhao Qin Lim; Piyush Khandelia; Brad Friedman; Eugene V Makeyev
Journal:  Genes Dev       Date:  2012-06-01       Impact factor: 11.361

7.  From cis-regulatory elements to complex RNPs and back.

Authors:  Fátima Gebauer; Thomas Preiss; Matthias W Hentze
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-07-01       Impact factor: 10.005

8.  The exon junction complex differentially marks spliced junctions.

Authors:  Jérôme Saulière; Nazmul Haque; Scot Harms; Isabelle Barbosa; Marco Blanchette; Hervé Le Hir
Journal:  Nat Struct Mol Biol       Date:  2010-09-05       Impact factor: 15.369

9.  The life of an mRNA in space and time.

Authors:  Ya'ara Ben-Ari; Yehuda Brody; Noa Kinor; Amir Mor; Toshiro Tsukamoto; David L Spector; Robert H Singer; Yaron Shav-Tal
Journal:  J Cell Sci       Date:  2010-04-27       Impact factor: 5.285

10.  Estrogen coordinates translation and transcription, revealing a role for NRSF in human breast cancer cells.

Authors:  Michael W Bronson; Sara Hillenmeyer; Richard W Park; Alexander S Brodsky
Journal:  Mol Endocrinol       Date:  2010-04-14
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