Literature DB >> 1922389

On the development of alternative antiepileptic drugs. Lack of enantioselectivity of the anticonvulsant activity, in contrast to teratogenicity, of 2-n-propyl-4-pentenoic acid and 2-n-propyl-4-pentynoic acid, analogues of the anticonvulsant drug valproic acid.

R S Hauck1, H Nau, M M Elmazar.   

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Year:  1991        PMID： 1922389     DOI： 10.1007/bf01134356

Source DB:  PubMed          Journal:  Naturwissenschaften        ISSN： 0028-1042


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  10 in total

Review 1.  Enantioselective aspects of drug action and disposition: therapeutic pitfalls.

Authors:  F Jamali; R Mehvar; F M Pasutto
Journal:  J Pharm Sci       Date:  1989-09       Impact factor: 3.534

2.  A simplified method of evaluating dose-effect experiments.

Authors:  J T LITCHFIELD; F WILCOXON
Journal:  J Pharmacol Exp Ther       Date:  1949-06       Impact factor: 4.030

Review 3.  Chirality. Clinical pharmacokinetic and pharmacodynamic considerations.

Authors:  E J Lee; K M Williams
Journal:  Clin Pharmacokinet       Date:  1990-05       Impact factor: 6.447

4.  Pharmacologic evaluation of various metabolites and analogs of valproic acid: teratogenic potencies in mice.

Authors:  H Nau; W Löscher
Journal:  Fundam Appl Toxicol       Date:  1986-05

Review 5.  Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.

Authors:  E A Swinyard
Journal:  Epilepsia       Date:  1969-06       Impact factor: 5.864

6.  [Structural bases of the teratogenic effects of the antiepileptic valproic acid. 2-n-propyl-4-pentenic acid, the first structural analogue with significantly higher teratogenic action than VPA].

Authors:  R S Hauck; H Nau
Journal:  Naturwissenschaften       Date:  1989-11

7.  Asymmetric synthesis and enantioselective teratogenicity of 2-n-propyl-4-pentenoic acid (4-en-VPA), an active metabolite of the anticonvulsant drug, valproic acid.

Authors:  R S Hauck; H Nau
Journal:  Toxicol Lett       Date:  1989-10       Impact factor: 4.372

8.  The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice.

Authors:  P E Keane; J Simiand; E Mendes; V Santucci; M Morre
Journal:  Neuropharmacology       Date:  1983-07       Impact factor: 5.250

9.  Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.

Authors:  H Nau; D Rating; S Koch; I Häuser; H Helge
Journal:  J Pharmacol Exp Ther       Date:  1981-12       Impact factor: 4.030

10.  Pharmacological evaluation of various metabolites and analogues of valproic acid. Anticonvulsant and toxic potencies in mice.

Authors:  W Löscher; H Nau
Journal:  Neuropharmacology       Date:  1985-05       Impact factor: 5.250
  10 in total
  3 in total

1.  Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3beta inhibition, and viral replication: a screening approach for new bipolar disorder drugs derived from the valproic acid core structure.

Authors:  B J Eickholt; G J Towers; W J Ryves; D Eikel; K Adley; L M J Ylinen; N H Chadborn; A J Harwood; H Nau; R S B Williams
Journal:  Mol Pharmacol       Date:  2005-02-01       Impact factor: 4.436

2.  The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA): asymmetric synthesis and highly stereoselective teratogenicity in mice.

Authors:  R S Hauck; H Nau
Journal:  Pharm Res       Date:  1992-07       Impact factor: 4.200

3.  Valpromide Inhibits Lytic Cycle Reactivation of Epstein-Barr Virus.

Authors:  Kelly L Gorres; Derek Daigle; Sudharshan Mohanram; Grace E McInerney; Danielle E Lyons; George Miller
Journal:  MBio       Date:  2016-03-01       Impact factor: 7.867
  3 in total

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