Literature DB >> 1921650

Cardiovascular actions of adenosines, but not adenosine receptors, differ in rat and guinea pig.

M Ueeda1, R D Thompson, W L Padgett, S Secunda, J W Daly, R A Olsson.   

Abstract

This study compared the structure-activity relationships of 16 analogues at the A1 and A2 adenosine receptors (A1AR, A2AR) of rat and guinea pig. Radioligand binding studies revealed no marked differences in the affinities of each analogue at the A1AR of brain cortex or the A2AR of brain striatum. Bioassay employing Langendorff heart preparations showed that the guinea pig is more sensitive than the rat to A1AR-mediated slowing of conduction through the atrioventricular node and, in some instances, to A2AR-mediated coronary vasodilation. That difference could reflect factors such as receptor density or efficacy of coupling to effector systems.

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Year:  1991        PMID： 1921650     DOI： 10.1016/0024-3205(91)90199-l

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  8 in total

1.  Contributions of A2A and A2B adenosine receptors in coronary flow responses in relation to the KATP channel using A2B and A2A/2B double-knockout mice.

Authors:  Maryam Sharifi Sanjani; Bunyen Teng; Thomas Krahn; Stephen Tilley; Catherine Ledent; S Jamal Mustafa
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-09-23       Impact factor: 4.733

2.  Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists.

Authors:  I van der Ploeg; S Ahlberg; F E Parkinson; R A Olsson; B B Fredholm
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-02       Impact factor: 3.000

3.  Inhibition of platelet aggregation by adenosine receptor agonists.

Authors:  G Cristalli; S Vittori; R D Thompson; W L Padgett; D Shi; J W Daly; R A Olsson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-06       Impact factor: 3.000

4.  Covalent binding of a selective agonist irreversibly activates guinea pig coronary artery A2 adenosine receptors.

Authors:  K Niiya; K A Jacobson; S K Silvia; R A Olsson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-05       Impact factor: 3.000

5.  Characterization of adenosine receptors in intact cultured heart cells.

Authors:  D el-Ani; K A Jacobson; A Shainberg
Journal:  Biochem Pharmacol       Date:  1994-08-17       Impact factor: 5.858

6.  Modelling of the pharmacodynamic interaction of an A1 adenosine receptor agonist and antagonist in vivo: N6-cyclopentyladenosine and 8-cyclopentyltheophylline.

Authors:  S Appel; R A Mathôt; M W Langemeijer; A P IJzerman; M Danhof
Journal:  Br J Pharmacol       Date:  1995-08       Impact factor: 8.739

Review 7.  Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.

Authors:  K A Jacobson; P J van Galen; M Williams
Journal:  J Med Chem       Date:  1992-02-07       Impact factor: 7.446

Review 8.  Adenosine A1 and A2 receptors: structure--function relationships.

Authors:  P J van Galen; G L Stiles; G Michaels; K A Jacobson
Journal:  Med Res Rev       Date:  1992-09       Impact factor: 12.944
  8 in total

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