| Literature DB >> 19215087 |
Gabriela Mustata1, Ariele Viacava Follis, Dalia I Hammoudeh, Steven J Metallo, Huabo Wang, Edward V Prochownik, John S Lazo, Ivet Bahar.
Abstract
A three-dimensional pharmacophore model was generated utilizing a set of known inhibitors of c-Myc-Max heterodimer formation. The model successfully identified a set of structurally diverse compounds with potential inhibitory activity against c-Myc. Nine compounds were tested in vitro, and four displayed affinities in the micromolar range and growth inhibitory activity against c-Myc-overexpressing cells. These studies demonstrate the applicability of pharmacophore modeling to the identification of novel and potentially more puissant inhibitors of the c-Myc oncoprotein.Entities:
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Year: 2009 PMID： 19215087 PMCID： PMC2765518 DOI： 10.1021/jm801278g
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446