Literature DB >> 19213593

Botulinum toxin prevents radiotherapy-induced salivary gland damage.

Afshin Teymoortash1, Felix Müller, Janko Juricko, Michael Bieker, Robert Mandic, Damiano Librizzi, Helmut Höffken, Andeas Pfestroff, Jochen Alfred Werner.   

Abstract

Radiotherapy of head and neck malignancies results in severe damage to salivary glands. Irradiation-induced sialadenitis with xerostomia leads to a significant deterioration of the quality of life which lasts life-long. Here we show in a preliminary study that intraglandular application of botulinum toxin performed prior to radiation reduces significantly the radiation induced toxicity of the glandular tissue in rats.

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Year:  2009        PMID： 19213593     DOI： 10.1016/j.oraloncology.2008.11.014

Source DB:  PubMed          Journal:  Oral Oncol        ISSN： 1368-8375            Impact factor:   5.337


  11 in total

1.  [Botulinum toxin A after microvascular ALT flap in a patient with (corrected) squamous cell carcinoma of the tongue].

Authors:  F Ihler; R Laskawi; C Matthias; H H Rustenbeck; M Canis
Journal:  HNO       Date:  2012-06       Impact factor: 1.284

Review 2.  Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers.

Authors:  Arjan Vissink; James B Mitchell; Bruce J Baum; Kirsten H Limesand; Siri Beier Jensen; Philip C Fox; Linda S Elting; Johannes A Langendijk; Robert P Coppes; Mary E Reyland
Journal:  Int J Radiat Oncol Biol Phys       Date:  2010-11-15       Impact factor: 7.038

3.  Botulinum Toxin Confers Radioprotection in Murine Salivary Glands.

Authors:  Youssef H Zeidan; Nan Xiao; Hongbin Cao; Christina Kong; Quynh-Thu Le; Davud Sirjani
Journal:  Int J Radiat Oncol Biol Phys       Date:  2015-12-29       Impact factor: 7.038

Review 4.  [Botulinum toxin in otorhinolaryngology - an update].

Authors:  R Laskawi; A Olthoff
Journal:  HNO       Date:  2017-10       Impact factor: 1.284

5.  Two-stage autotransplantation of human submandibular gland: a novel approach to treat postradiogenic xerostomia.

Authors:  Rudolf Hagen; Matthias Scheich; Norbert Kleinsasser; Marc Burghartz
Journal:  Eur Arch Otorhinolaryngol       Date:  2015-08-19       Impact factor: 2.503

6.  Monte Carlo-based 3-dimensional dosimetry of salivary glands in radioiodine treatment of differentiated thyroid cancer estimated using 124I PET.

Authors:  R F Hobbs; W Jentzen; A Bockisch; G Sgouros
Journal:  Q J Nucl Med Mol Imaging       Date:  2013-03       Impact factor: 2.346

Review 7.  Cost-effectiveness landscape analysis of treatments addressing xerostomia in patients receiving head and neck radiation therapy.

Authors:  Laura S Sasportas; Drew N Hosford; Maria A Sodini; Dale J Waters; Elizabeth A Zambricki; Joëlle K Barral; Edward E Graves; Todd J Brinton; Paul G Yock; Quynh-Thu Le; Davud Sirjani
Journal:  Oral Surg Oral Med Oral Pathol Oral Radiol       Date:  2013-05-03

Review 8.  Therapeutic Strategies for Dry Mouth Management with Emphasis on Electrostimulation as a Treatment Option.

Authors:  Amela Tulek; Aida Mulic; Martine Hogset; Tor Paaske Utheim; Amer Sehic
Journal:  Int J Dent       Date:  2021-10-22

9.  Shear wave elastography: a new noninvasive tool to assess the intensity of fibrosis of irradiated salivary glands in head and neck cancer patients.

Authors:  Jarosław Kałużny; Tomasz Kopeć; Ewelina Szczepanek-Parulska; Adam Stangierski; Edyta Gurgul; Marek Ruchała; Piotr Milecki; Małgorzata Wierzbicka
Journal:  Biomed Res Int       Date:  2014-08-17       Impact factor: 3.411

10.  Safety and Efficacy of Botulinum Toxin to Preserve Gland Function after Radiotherapy in Patients with Head and Neck Cancer: A Prospective, Randomized, Placebo-Controlled, Double-Blinded Phase I Clinical Trial.

Authors:  Afshin Teymoortash; Andreas Pfestroff; Andrea Wittig; Nora Franke; Stephan Hoch; Susanne Harnisch; Carmen Schade-Brittinger; Helmut Hoeffken; Rita Engenhart-Cabillic; Markus Brugger; Konstantin Strauch
Journal:  PLoS One       Date:  2016-03-18       Impact factor: 3.240
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