Literature DB >> 16492558

Targeting HSP90 to halt neurodegeneration.

Kathleen A Gallo1.   

Abstract

Activation of c-jun N-terminal kinase (JNK) signaling is associated with neuronal cell death. As described in this issue of Chemistry & Biology, cell-based screening efforts yielded a compound, AEG3482, which interacts with heat shock protein 90 leading to inhibition of JNK and blockade of neuronal apoptosis .

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Year:  2006        PMID： 16492558     DOI： 10.1016/j.chembiol.2006.02.003

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  11 in total

1.  Collaboration of geldanamycin-activated P70S6K and Hsp70 against beta-amyloid-induced hippocampal apoptosis: an approach to long-term memory and learning.

Authors:  Nayereh Zare; Fereshteh Motamedi; Hadi Digaleh; Fariba Khodagholi; Nader Maghsoudi
Journal:  Cell Stress Chaperones       Date:  2015-01-10       Impact factor: 3.667

2.  Endogenous 3,4-dihydroxyphenylalanine and dopaquinone modifications on protein tyrosine: links to mitochondrially derived oxidative stress via hydroxyl radical.

Authors:  Xu Zhang; Matthew E Monroe; Baowei Chen; Mark H Chin; Tyler H Heibeck; Athena A Schepmoes; Feng Yang; Brianne O Petritis; David G Camp; Joel G Pounds; Jon M Jacobs; Desmond J Smith; Diana J Bigelow; Richard D Smith; Wei-Jun Qian
Journal:  Mol Cell Proteomics       Date:  2010-02-02       Impact factor: 5.911

Review 3.  Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.

Authors:  Alison Donnelly; Brian S J Blagg
Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530

4.  3-Arylcoumarin derivatives manifest anti-proliferative activity through Hsp90 inhibition.

Authors:  Huiping Zhao; Bin Yan; Laura B Peterson; Brian S J Blagg
Journal:  ACS Med Chem Lett       Date:  2012-02-26       Impact factor: 4.345

Review 5.  Natural product inhibitors of Hsp90: potential leads for drug discovery.

Authors:  M W Amolins; B S J Blagg
Journal:  Mini Rev Med Chem       Date:  2009-02       Impact factor: 3.862

6.  Low dose Hsp90 inhibitor 17AAG protects neural progenitor cells from ischemia induced death.

Authors:  Eric Bradley; Xiaying Zhao; Rebecca Wang; Darrell Brann; Erhard Bieberich; Guanghu Wang
Journal:  J Cell Commun Signal       Date:  2014-10-04       Impact factor: 5.782

Review 7.  To fold or not to fold: modulation and consequences of Hsp90 inhibition.

Authors:  Laura B Peterson; Brian S J Blagg
Journal:  Future Med Chem       Date:  2009-05       Impact factor: 3.808

8.  A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.

Authors:  Rui Xiong; Wenbo Zhou; David Siegel; Russell R A Kitson; Curt R Freed; Christopher J Moody; David Ross
Journal:  Mol Pharmacol       Date:  2015-09-24       Impact factor: 4.436

Review 9.  The role and therapeutic potential of Hsp90, Hsp70, and smaller heat shock proteins in peripheral and central neuropathies.

Authors:  Subhabrata Chaudhury; Bradley M Keegan; Brian S J Blagg
Journal:  Med Res Rev       Date:  2020-08-25       Impact factor: 12.944

10.  Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.

Authors:  Russell R A Kitson; Chuan-Hsin Chang; Rui Xiong; Huw E L Williams; Adrienne L Davis; William Lewis; Donna L Dehn; David Siegel; S Mark Roe; Chrisostomos Prodromou; David Ross; Christopher J Moody
Journal:  Nat Chem       Date:  2013-03-10       Impact factor: 24.427
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