Literature DB >> 19194008

Crystallization and diffraction of an Lhx4-Isl2 complex.

Morgan S Gadd1, David B Langley, J Mitchell Guss, Jacqueline M Matthews.   

Abstract

A stable intramolecular complex comprising the LIM domains of the LIM-homeodomain protein Lhx4 tethered to a peptide region of Isl2 has been engineered, purified and crystallized. The monoclinic crystals belonged to space group P2(1), with unit-cell parameters a = 46.8, b = 88.7, c = 49.9 A, beta = 111.9 degrees, and diffracted to 2.16 A resolution.

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Year:  2009        PMID： 19194008      PMCID： PMC2635870          DOI： 10.1107/S1744309108043431

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  16 in total

Review 1.  The LIM domain: regulation by association.

Authors:  I Bach
Journal:  Mech Dev       Date:  2000-03-01       Impact factor: 1.882

Review 2.  A LIM-homeodomain code for development and evolution of forebrain connectivity.

Authors:  Isabelle Bachy; Vieri Failli; Sylvie Rétaux
Journal:  Neuroreport       Date:  2002-02-11       Impact factor: 1.837

3.  LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.

Authors:  Joshua P Thaler; Soo-Kyung Lee; Linda W Jurata; Gordon N Gill; Samuel L Pfaff
Journal:  Cell       Date:  2002-07-26       Impact factor: 41.582

4.  Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain.

Authors:  O Karlsson; S Thor; T Norberg; H Ohlsson; T Edlund
Journal:  Nature       Date:  1990-04-26       Impact factor: 49.962

5.  Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes.

Authors:  J E Deane; E Sum; J P Mackay; G J Lindeman; J E Visvader; J M Matthews
Journal:  Protein Eng       Date:  2001-07

Review 6.  LIM-homeodomain genes in mammalian development and human disease.

Authors:  Chad S Hunter; Simon J Rhodes
Journal:  Mol Biol Rep       Date:  2005-06       Impact factor: 2.316

7.  Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes.

Authors:  Mugdha Bhati; Christopher Lee; Amy L Nancarrow; Mihwa Lee; Vanessa J Craig; Ingolf Bach; J Mitchell Guss; Joel P Mackay; Jacqueline M Matthews
Journal:  EMBO J       Date:  2008-06-26       Impact factor: 11.598

8.  Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex.

Authors:  Janet E Deane; Daniel P Ryan; Margaret Sunde; Megan J Maher; J Mitchell Guss; Jane E Visvader; Jacqueline M Matthews
Journal:  EMBO J       Date:  2004-09-02       Impact factor: 11.598

9.  Crystallization of an Lhx3-Isl1 complex.

Authors:  Mugdha Bhati; Mihwa Lee; Amy Louise Nancarrow; Ingolf Bach; J Mitchell Guss; Jacqueline Mary Matthews
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-03-21

Review 10.  LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins.

Authors:  Jacqueline M Matthews; Jane E Visvader
Journal:  EMBO Rep       Date:  2003-12       Impact factor: 8.807
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  5 in total

1.  Crystallization and diffraction of an Isl1-Ldb1 complex.

Authors:  Morgan S Gadd; David A Jacques; J Mitchell Guss; Jacqueline M Matthews
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-10-30

2.  A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.

Authors:  Morgan S Gadd; David A Jacques; Ivan Nisevic; Vanessa J Craig; Ann H Kwan; J Mitchell Guss; Jacqueline M Matthews
Journal:  J Biol Chem       Date:  2013-06-09       Impact factor: 5.157

3.  Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.

Authors:  Morgan S Gadd; Mugdha Bhati; Cy M Jeffries; David B Langley; Jill Trewhella; J Mitchell Guss; Jacqueline M Matthews
Journal:  J Biol Chem       Date:  2011-10-24       Impact factor: 5.157

4.  Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions.

Authors:  Mugdha Bhati; Christopher Lee; Morgan S Gadd; Cy M Jeffries; Ann Kwan; Andrew E Whitten; Jill Trewhella; Joel P Mackay; Jacqueline M Matthews
Journal:  PLoS One       Date:  2012-07-25       Impact factor: 3.240

5.  Interactions between LHX3- and ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans.

Authors:  Mugdha Bhati; Estelle Llamosas; David A Jacques; Cy M Jeffries; Siavoush Dastmalchi; Nina Ripin; Hannah R Nicholas; Jacqueline M Matthews
Journal:  Sci Rep       Date:  2017-07-04       Impact factor: 4.379
  5 in total

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