Literature DB >> 18391431

Crystallization of an Lhx3-Isl1 complex.

Mugdha Bhati1, Mihwa Lee, Amy Louise Nancarrow, Ingolf Bach, J Mitchell Guss, Jacqueline Mary Matthews.   

Abstract

A stable intramolecular complex comprising the LIM domains of the LIM-homeodomain protein Lhx3 tethered to a peptide region of Isl1 has been engineered, purified and crystallized. The monoclinic crystals belong to space group C2, with unit-cell parameters a = 119, b = 62.2, c = 51.9 A, beta = 91.6 degrees , and diffract to 2.05 A resolution.

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Year:  2008        PMID： 18391431      PMCID： PMC2374238          DOI： 10.1107/S174430910800691X

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  9 in total

Review 1.  The LIM domain: regulation by association.

Authors:  I Bach
Journal:  Mech Dev       Date:  2000-03-01       Impact factor: 1.882

2.  LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions.

Authors:  Joshua P Thaler; Soo-Kyung Lee; Linda W Jurata; Gordon N Gill; Samuel L Pfaff
Journal:  Cell       Date:  2002-07-26       Impact factor: 41.582

3.  The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.

Authors:  L W Jurata; S L Pfaff; G N Gill
Journal:  J Biol Chem       Date:  1998-02-06       Impact factor: 5.157

4.  Solvent content of protein crystals.

Authors:  B W Matthews
Journal:  J Mol Biol       Date:  1968-04-28       Impact factor: 5.469

Review 5.  Neural development. A 'LIM code' for motor neurons?

Authors:  A Lumsden
Journal:  Curr Biol       Date:  1995-05-01       Impact factor: 10.834

6.  1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complex.

Authors:  Christopher Lee; Amy L Nancarrow; Ingolf Bach; Joel P Mackay; Jacqueline M Matthews
Journal:  J Biomol NMR       Date:  2005-11       Impact factor: 2.835

7.  The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development.

Authors:  C Zeng; N J Justice; S Abdelilah; Y M Chan; L Y Jan; Y N Jan
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

8.  Overexpression Beadex mutations and loss-of-function heldup-a mutations in Drosophila affect the 3' regulatory and coding components, respectively, of the Dlmo gene.

Authors:  M Shoresh; S Orgad; O Shmueli; R Werczberger; D Gelbaum; S Abiri; D Segal
Journal:  Genetics       Date:  1998-09       Impact factor: 4.562

9.  Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function.

Authors:  M Milán; F J Diaz-Benjumea; S M Cohen
Journal:  Genes Dev       Date:  1998-09-15       Impact factor: 11.361
  9 in total
  11 in total

1.  Crystallization and diffraction of an Lhx4-Isl2 complex.

Authors:  Morgan S Gadd; David B Langley; J Mitchell Guss; Jacqueline M Matthews
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-01-31

2.  Crystallization and diffraction of an Isl1-Ldb1 complex.

Authors:  Morgan S Gadd; David A Jacques; J Mitchell Guss; Jacqueline M Matthews
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-10-30

Review 3.  Linkers in the structural biology of protein-protein interactions.

Authors:  Vishnu Priyanka Reddy Chichili; Veerendra Kumar; J Sivaraman
Journal:  Protein Sci       Date:  2013-01-08       Impact factor: 6.725

4.  A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.

Authors:  Morgan S Gadd; David A Jacques; Ivan Nisevic; Vanessa J Craig; Ann H Kwan; J Mitchell Guss; Jacqueline M Matthews
Journal:  J Biol Chem       Date:  2013-06-09       Impact factor: 5.157

5.  A Multi-step Transcriptional and Chromatin State Cascade Underlies Motor Neuron Programming from Embryonic Stem Cells.

Authors:  Silvia Velasco; Mahmoud M Ibrahim; Akshay Kakumanu; Görkem Garipler; Begüm Aydin; Mohamed Ahmed Al-Sayegh; Antje Hirsekorn; Farah Abdul-Rahman; Rahul Satija; Uwe Ohler; Shaun Mahony; Esteban O Mazzoni
Journal:  Cell Stem Cell       Date:  2016-12-08       Impact factor: 24.633

6.  Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.

Authors:  Morgan S Gadd; Mugdha Bhati; Cy M Jeffries; David B Langley; Jill Trewhella; J Mitchell Guss; Jacqueline M Matthews
Journal:  J Biol Chem       Date:  2011-10-24       Impact factor: 5.157

7.  Lmx1a is required for segregation of sensory epithelia and normal ear histogenesis and morphogenesis.

Authors:  David H Nichols; Sarah Pauley; Israt Jahan; Kirk W Beisel; Kathleen J Millen; Bernd Fritzsch
Journal:  Cell Tissue Res       Date:  2008-11-05       Impact factor: 5.249

8.  Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes.

Authors:  Mugdha Bhati; Christopher Lee; Amy L Nancarrow; Mihwa Lee; Vanessa J Craig; Ingolf Bach; J Mitchell Guss; Joel P Mackay; Jacqueline M Matthews
Journal:  EMBO J       Date:  2008-06-26       Impact factor: 11.598

9.  Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions.

Authors:  Mugdha Bhati; Christopher Lee; Morgan S Gadd; Cy M Jeffries; Ann Kwan; Andrew E Whitten; Jill Trewhella; Joel P Mackay; Jacqueline M Matthews
Journal:  PLoS One       Date:  2012-07-25       Impact factor: 3.240

10.  Interactions between LHX3- and ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans.

Authors:  Mugdha Bhati; Estelle Llamosas; David A Jacques; Cy M Jeffries; Siavoush Dastmalchi; Nina Ripin; Hannah R Nicholas; Jacqueline M Matthews
Journal:  Sci Rep       Date:  2017-07-04       Impact factor: 4.379
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