BACKGROUND: Mounting evidence implicates obesity as a major risk factor for asthma. Leptin and adiponectin produced by fat tissues play a critical role in the regulation of body weight and allergic inflammation. OBJECTIVE: The aim of this study was to evaluate the effects of leptin and adiponectin on development of asthma. METHODS: We measured the leptin and adiponectin in serum from patients with asthma (n = 60) and normal control subjects (n = 30) by enzyme-linked immunosorbent assay. RESULTS: Logarithmic leptin and adiponectin concentration was not different between asthmatics and control subjects. Although the logarithmic adiponectin level was not different by gender in asthmatics, the logarithmic leptin concentration was significantly higher in females than in male asthmatics (2.41 +/- 0.05 ng/mL vs. 2.01 +/- 0.05 ng/mL, p = 0.001). The leptin/adiponectin ratio was also significantly higher in females than in male asthmatics. The leptin/adiponectin ratio was correlated with body mass index (r = 0.210, p = 0.05) in asthmatics. CONCLUSION: Our results suggest that serum leptin and adiponectin may be associated with gender and obesity regardless of development of asthma.
BACKGROUND: Mounting evidence implicates obesity as a major risk factor for asthma. Leptin and adiponectin produced by fat tissues play a critical role in the regulation of body weight and allergic inflammation. OBJECTIVE: The aim of this study was to evaluate the effects of leptin and adiponectin on development of asthma. METHODS: We measured the leptin and adiponectin in serum from patients with asthma (n = 60) and normal control subjects (n = 30) by enzyme-linked immunosorbent assay. RESULTS: Logarithmic leptin and adiponectin concentration was not different between asthmatics and control subjects. Although the logarithmic adiponectin level was not different by gender in asthmatics, the logarithmic leptin concentration was significantly higher in females than in male asthmatics (2.41 +/- 0.05 ng/mL vs. 2.01 +/- 0.05 ng/mL, p = 0.001). The leptin/adiponectin ratio was also significantly higher in females than in male asthmatics. The leptin/adiponectin ratio was correlated with body mass index (r = 0.210, p = 0.05) in asthmatics. CONCLUSION: Our results suggest that serum leptin and adiponectin may be associated with gender and obesity regardless of development of asthma.
Authors: Juanita H J Vernooy; Niki D J Ubags; Guy G Brusselle; Jan Tavernier; Benjamin T Suratt; Guy F Joos; Emiel F M Wouters; Ken R Bracke Journal: Pulm Pharmacol Ther Date: 2013-03-27 Impact factor: 3.410
Authors: Gina N Calco; Becky J Proskocil; David B Jacoby; Allison D Fryer; Zhenying Nie Journal: Am J Physiol Lung Cell Mol Physiol Date: 2021-10-20 Impact factor: 6.011
Authors: Stephanie Lovinsky-Desir; Stephanie J Lussier; Agustin Calatroni; Peter J Gergen; Katherine Rivera-Spoljaric; Leonard B Bacharier; Aliva De; George T O'Connor; Megan T Sandel; Robert A Wood; Emilio Arteaga-Solis; James E Gern; Meyer Kattan Journal: J Allergy Clin Immunol Date: 2021-06-22 Impact factor: 10.793