Amy Lynn Conrad1, Lynn Richman, Peg Nopoulos, Scott Dailey. 1. The University of Iowa College of Medicine, Psychiatry Research, and University of Iowa Hospitals and Clinics, Otolaryngology, Iowa City, IA 52242, USA. Amy-L-Conrad@uiowa.edu
Abstract
OBJECTIVE: Evaluate neuropsychological functioning in children with non-syndromic cleft of the lip and/or palate (NSCL/P) through profile variance within type of cleft and comparisons to controls. METHODS: Children ages 7 to 17 years participated; 66 had a diagnosis of NSCL/P and 87 were healthy controls. Neuropsychological tests of language, visual-perceptual, executive functioning, and memory skills were administered. Between- and within-group differences were assessed. RESULTS: Within cleft types, children with NSCLP had an even profile with equal Verbal and Performance IQ (VIQ and PIQ, respectively). Children with non-syndromic cleft palate only (NSCP) had significantly lower VIQ than PIQ, while children with non-syndromic cleft lip only (NSCL) showed a nonsignificant trend for higher VIQ than PIQ. Overall, subjects with NSCL/P performed lower on measures of expressive language and verbal memory than controls. CONCLUSIONS: While deficits in verbal and memory skills for children with NSCL/P remain apparent, there is still uncertainty around the possible influence of cleft type on the pattern of deficits.
OBJECTIVE: Evaluate neuropsychological functioning in children with non-syndromic cleft of the lip and/or palate (NSCL/P) through profile variance within type of cleft and comparisons to controls. METHODS:Children ages 7 to 17 years participated; 66 had a diagnosis of NSCL/P and 87 were healthy controls. Neuropsychological tests of language, visual-perceptual, executive functioning, and memory skills were administered. Between- and within-group differences were assessed. RESULTS: Within cleft types, children with NSCLP had an even profile with equal Verbal and Performance IQ (VIQ and PIQ, respectively). Children with non-syndromic cleft palate only (NSCP) had significantly lower VIQ than PIQ, while children with non-syndromic cleft lip only (NSCL) showed a nonsignificant trend for higher VIQ than PIQ. Overall, subjects with NSCL/P performed lower on measures of expressive language and verbal memory than controls. CONCLUSIONS: While deficits in verbal and memory skills for children with NSCL/P remain apparent, there is still uncertainty around the possible influence of cleft type on the pattern of deficits.
Authors: George L Wehby; Brent Collet; Sheila Barron; Paul A Romitti; Timothy N Ansley; Matthew Speltz Journal: Pediatrics Date: 2014-05 Impact factor: 7.124
Authors: Amy L Conrad; Scott Dailey; Lynn Richman; John Canady; Michael P Karnell; Eric Axelson; Peg Nopoulos Journal: Cleft Palate Craniofac J Date: 2010-09
Authors: Harry Hochheiser; Bruce J Aronow; Kristin Artinger; Terri H Beaty; James F Brinkley; Yang Chai; David Clouthier; Michael L Cunningham; Michael Dixon; Leah Rae Donahue; Scott E Fraser; Benedikt Hallgrimsson; Junichi Iwata; Ophir Klein; Mary L Marazita; Jeffrey C Murray; Stephen Murray; Fernando Pardo-Manuel de Villena; John Postlethwait; Steven Potter; Linda Shapiro; Richard Spritz; Axel Visel; Seth M Weinberg; Paul A Trainor Journal: Dev Biol Date: 2011-03-31 Impact factor: 3.582