PURPOSE: To illustrate modern survival models with focus on the temporal dynamics of intensive care data. A typical situation is given in which time-dependent exposures and competing events are present. METHODS: We briefly review the following established statistical methods: logistic regression, regression models for event-specific hazards and the subdistribution hazard. These approaches are compared by showing advantages as well as disadvantages. All methods are applied to real data from a study of day-by-day ICU surveillance. RESULTS: Standard logistic regression ignores the time-dependent nature of the data and is only a crude approach. Cumulative hazards and probability plots add important information and provide a deep insight into the temporal dynamics. CONCLUSION: This paper might help to encourage researchers working in hospital epidemiology to apply adequate statistical models to complex medical questions.
PURPOSE: To illustrate modern survival models with focus on the temporal dynamics of intensive care data. A typical situation is given in which time-dependent exposures and competing events are present. METHODS: We briefly review the following established statistical methods: logistic regression, regression models for event-specific hazards and the subdistribution hazard. These approaches are compared by showing advantages as well as disadvantages. All methods are applied to real data from a study of day-by-day ICU surveillance. RESULTS: Standard logistic regression ignores the time-dependent nature of the data and is only a crude approach. Cumulative hazards and probability plots add important information and provide a deep insight into the temporal dynamics. CONCLUSION: This paper might help to encourage researchers working in hospital epidemiology to apply adequate statistical models to complex medical questions.
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