Literature DB >> 19183791

DNA methylation signature analysis: how easy is it to perform?

Christina Piperi1, Elena Farmaki, Fotis Vlastos, Athanasios G Papavassiliou, Nadine Martinet.   

Abstract

Epigenetic changes, or heritable alterations in gene function that do not affect DNA sequence, are rapidly gaining acceptance as co-conspirators in carcinogenesis. Although DNA methylation signature analysis by methylation-specific polymerase chain reaction has been a breakthrough method in speed and sensitivity for gene methylation studies, several factors still limit its application as a routine diagnostic and prognostic test.

Keywords:  DNA methylation; cancer diagnosis; carcinogenesis; epigenetic change; methylation-specific PCR

Mesh：

Substances：

Year:  2008        PMID： 19183791      PMCID： PMC2628070     

Source DB:  PubMed          Journal:  J Biomol Tech        ISSN： 1524-0215


  14 in total

Review 1.  DNA methylation in health and disease.

Authors:  K D Robertson; A P Wolffe
Journal:  Nat Rev Genet       Date:  2000-10       Impact factor: 53.242

Review 2.  DNA methylation, genomic imprinting and cancer.

Authors:  A P Feinberg
Journal:  Curr Top Microbiol Immunol       Date:  2000       Impact factor: 4.291

3.  Bisulfite genomic sequencing: systematic investigation of critical experimental parameters.

Authors:  C Grunau; S J Clark; A Rosenthal
Journal:  Nucleic Acids Res       Date:  2001-07-01       Impact factor: 16.971

4.  Methylcytosine-selective fluorescence quenching by osmium complexation.

Authors:  Kazuo Tanaka; Kazuki Tainaka; Akimitsu Okamoto
Journal:  Bioorg Med Chem       Date:  2006-12-15       Impact factor: 3.641

5.  In-tube DNA methylation profiling by fluorescence melting curve analysis.

Authors:  J Worm; A Aggerholm; P Guldberg
Journal:  Clin Chem       Date:  2001       Impact factor: 8.327

6.  MethDB--a public database for DNA methylation data.

Authors:  C Grunau; E Renault; A Rosenthal; G Roizes
Journal:  Nucleic Acids Res       Date:  2001-01-01       Impact factor: 16.971

7.  Heterogeneity of DNA methylation status analyzed by bisulfite-PCR-SSCP and correlation with clinico-pathological characteristics in colorectal cancer.

Authors:  M Maekawa; K Sugano; M Ushiama; N Fukayama; K Nomoto; H Kashiwabara; S Fujita; T Kakizoe
Journal:  Clin Chem Lab Med       Date:  2001-02       Impact factor: 3.694

8.  Profiling DNA methylation by melting analysis.

Authors:  Per Guldberg; Jesper Worm; Kirsten Grønbaek
Journal:  Methods       Date:  2002-06       Impact factor: 3.608

9.  Number of CpG islands and genes in human and mouse.

Authors:  F Antequera; A Bird
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205

10.  Polymerase chain reaction-based methods of DNA methylation analysis.

Authors:  Ze-Jun Liu; Masato Maekawa
Journal:  Anal Biochem       Date:  2003-06-15       Impact factor: 3.365
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  3 in total

1.  Pyrosequencing Analysis of MGMT Promoter Methylation in Meningioma.

Authors:  Ioannis Panagopoulos; Ludmila Gorunova; Henning Leske; Pitt Niehusmann; Lene E Johannessen; Julie Staurseth; Nina Øino; Torstein R Meling; Sverre Heim; Francesca Micci; Petter Brandal
Journal:  Cancer Genomics Proteomics       Date:  2018 Sep-Oct       Impact factor: 4.069

2.  Tumor mismatch repair immunohistochemistry and DNA MLH1 methylation testing of patients with endometrial cancer diagnosed at age younger than 60 years optimizes triage for population-level germline mismatch repair gene mutation testing.

Authors:  Daniel D Buchanan; Yen Y Tan; Michael D Walsh; Mark Clendenning; Alexander M Metcalf; Kaltin Ferguson; Sven T Arnold; Bryony A Thompson; Felicity A Lose; Michael T Parsons; Rhiannon J Walters; Sally-Ann Pearson; Margaret Cummings; Martin K Oehler; Penelope B Blomfield; Michael A Quinn; Judy A Kirk; Colin J Stewart; Andreas Obermair; Joanne P Young; Penelope M Webb; Amanda B Spurdle
Journal:  J Clin Oncol       Date:  2013-12-09       Impact factor: 44.544

3.  Promoter Hypermethylation and Decreased Expression of Syncytin-1 in Pancreatic Adenocarcinomas.

Authors:  Qinsheng Lu; Jinping Li; Christopher Senkowski; Zuoqing Tang; Jianhao Wang; Tianhe Huang; Xue Wang; Karen Terry; Steven Brower; Wayne Glasgow; Haibin Chen; Shi-Wen Jiang
Journal:  PLoS One       Date:  2015-07-31       Impact factor: 3.240
  3 in total

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