Literature DB >> 11262868

DNA methylation in health and disease.

K D Robertson1, A P Wolffe.   

Abstract

DNA methylation has recently moved to centre stage in the aetiology of human neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These diseases result from the misregulation of genes that occurs with the loss of appropriate epigenetic controls during neuronal development. Recent advances have connected DNA methylation to chromatin-remodelling enzymes, and understanding this link will be central to the design of new therapeutic tools.

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Year:  2000        PMID： 11262868     DOI： 10.1038/35049533

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  254 in total

1.  DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.

Authors:  G Fan; C Beard; R Z Chen; G Csankovszki; Y Sun; M Siniaia; D Biniszkiewicz; B Bates; P P Lee; R Kuhn; A Trumpp; C Poon; C B Wilson; R Jaenisch
Journal:  J Neurosci       Date:  2001-02-01       Impact factor: 6.167

Review 2.  Above and within the genome: epigenetics past and present.

Authors:  F D Urnov; A P Wolffe
Journal:  J Mammary Gland Biol Neoplasia       Date:  2001-04       Impact factor: 2.673

3.  Methylation patterns and mathematical models reveal dynamics of stem cell turnover in the human colon.

Authors:  S Ro; B Rannala
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-11       Impact factor: 11.205

4.  Methylation-dependent silencing at the H19 imprinting control region by MeCP2.

Authors:  Robert A Drewell; Carolyn J Goddard; Jean O Thomas; M Azim Surani
Journal:  Nucleic Acids Res       Date:  2002-03-01       Impact factor: 16.971

5.  Bisulfite genomic sequencing of microdissected cells.

Authors:  A Kerjean; A Vieillefond; N Thiounn; M Sibony; M Jeanpierre; P Jouannet
Journal:  Nucleic Acids Res       Date:  2001-11-01       Impact factor: 16.971

Review 6.  The marks, mechanisms and memory of epigenetic states in mammals.

Authors:  V K Rakyan; J Preis; H D Morgan; E Whitelaw
Journal:  Biochem J       Date:  2001-05-15       Impact factor: 3.857

7.  Analysis and accurate quantification of CpG methylation by MALDI mass spectrometry.

Authors:  Jörg Tost; Philipp Schatz; Matthias Schuster; Kurt Berlin; Ivo Glynne Gut
Journal:  Nucleic Acids Res       Date:  2003-05-01       Impact factor: 16.971

8.  Downregulation of Gadd45beta expression by hepatitis C virus leads to defective cell cycle arrest.

Authors:  Martin R Higgs; Hervé Lerat; Jean-Michel Pawlotsky
Journal:  Cancer Res       Date:  2010-06-08       Impact factor: 12.701

9.  6-Thioguanine perturbs cytosine methylation at the CpG dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.

Authors:  Hongxia Wang; Yinsheng Wang
Journal:  Biochemistry       Date:  2009-03-17       Impact factor: 3.162

10.  Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation.

Authors:  Peyman Golshani; Leah Hutnick; Felix Schweizer; Guoping Fan
Journal:  Thalamus Relat Syst       Date:  2005-09
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