Literature DB >> 19180614

Evidence for a stereoelectronic effect in human oxygen sensing.

Christoph Loenarz1, Jasmin Mecinović, Rasheduzzaman Chowdhury, Luke A McNeill, Emily Flashman, Christopher J Schofield.   

Abstract

How PHDs achieve specificity: trans-4-prolyl hydroxylation of the transcription factor HIF occurs with stereochemical retention. Substrate-analogue studies show how the von Hippel Lindau tumor suppressor protein (pVHL) and the oxygen-sensing hydroxylases (PHDs) achieve specificity for hydroxyprolyl/prolyl residues for the C(4)-exo/endo prolyl conformations, respectively.

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Year:  2009        PMID： 19180614     DOI： 10.1002/anie.200805427

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  24 in total

1.  Hypoxia sensing goes gauche.

Authors:  Danica Galonić Fujimori
Journal:  Nat Chem Biol       Date:  2009-04       Impact factor: 15.040

2.  Skp1 prolyl 4-hydroxylase of dictyostelium mediates glycosylation-independent and -dependent responses to O2 without affecting Skp1 stability.

Authors:  Dongmei Zhang; Hanke van der Wel; Jennifer M Johnson; Christopher M West
Journal:  J Biol Chem       Date:  2011-11-29       Impact factor: 5.157

Review 3.  Prolyl 4-hydroxylase.

Authors:  Kelly L Gorres; Ronald T Raines
Journal:  Crit Rev Biochem Mol Biol       Date:  2010-04       Impact factor: 8.250

4.  Requirements for Skp1 processing by cytosolic prolyl 4(trans)-hydroxylase and α-N-acetylglucosaminyltransferase enzymes involved in O₂ signaling in dictyostelium.

Authors:  Hanke van der Wel; Jennifer M Johnson; Yuechi Xu; Chamini V Karunaratne; Kyle D Wilson; Yusuf Vohra; Geert-Jan Boons; Carol M Taylor; Brad Bendiak; Christopher M West
Journal:  Biochemistry       Date:  2011-02-09       Impact factor: 3.162

5.  Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α.

Authors:  Dennis L Buckley; Jeffrey L Gustafson; Inge Van Molle; Anke G Roth; Hyun Seop Tae; Peter C Gareiss; William L Jorgensen; Alessio Ciulli; Craig M Crews
Journal:  Angew Chem Int Ed Engl       Date:  2012-10-12       Impact factor: 15.336

6.  Quantifying the Binding Interaction between the Hypoxia-Inducible Transcription Factor and the von Hippel-Lindau Suppressor.

Authors:  Carmen Domene; Christian Jorgensen; Kenno Vanommeslaeghe; Christopher J Schofield; Alexander MacKerell
Journal:  J Chem Theory Comput       Date:  2015-08-11       Impact factor: 6.006

Review 7.  Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer.

Authors:  Peter J Ratcliffe
Journal:  J Physiol       Date:  2013-02-11       Impact factor: 5.182

8.  Dissecting fragment-based lead discovery at the von Hippel-Lindau protein:hypoxia inducible factor 1α protein-protein interface.

Authors:  Inge Van Molle; Andreas Thomann; Dennis L Buckley; Ernest C So; Steffen Lang; Craig M Crews; Alessio Ciulli
Journal:  Chem Biol       Date:  2012-10-26

9.  The crystal structure of an algal prolyl 4-hydroxylase complexed with a proline-rich peptide reveals a novel buried tripeptide binding motif.

Authors:  M Kristian Koski; Reija Hieta; Maija Hirsilä; Anna Rönkä; Johanna Myllyharju; Rik K Wierenga
Journal:  J Biol Chem       Date:  2009-06-24       Impact factor: 5.157

10.  Inhibition of the histone demethylase JMJD2E by 3-substituted pyridine 2,4-dicarboxylates.

Authors:  Armin Thalhammer; Jasmin Mecinović; Christoph Loenarz; Anthony Tumber; Nathan R Rose; Tom D Heightman; Christopher J Schofield
Journal:  Org Biomol Chem       Date:  2010-11-15       Impact factor: 3.876
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