Literature DB >> 19169658

[Use of zolpidem and zopiclone on private prescriptions between 1993 and 2007].

F Hoffmann1, W Scharffetter, G Glaeske.   

Abstract

OBJECTIVE: Aim of this study was to analyse the amount of so-called private prescriptions of zolpidem and zopiclone (Z drugs) over a 15-year period in Germany. Any doctor can prescribe drugs privately. Private prescriptions are fully funded by the patients. At present the total number of doctors' prescriptions in Germany is undocumented because this information is not recorded in insurance claims data. This may be one reason why physicians prescribe drugs that are associated with abuse and dependence (such as Z drugs) more frequently on private prescriptions.
METHODS: We compared utilization data from statutory health insurance claims with the purchasing statistics from public pharmacies over the years 1993-2007.
RESULTS: Throughout the study period, purchases of zolpidem and zopiclone increased from 1.4 million to 3.7 million packages and 0.8 million to 3.9 million packages, respectively. A constantly rising proportion of private prescriptions for zolpidem resp. zopiclone were issued between 1993 (+6% resp. +6%), 1999 (+43% resp. +34%), and 2007 (+122% resp. +72%).
CONCLUSION: Since their approval in Germany, zopiclone and especially zolpidem have frequently been dispensed on private prescriptions.

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Year:  2009        PMID: 19169658     DOI: 10.1007/s00115-008-2648-2

Source DB:  PubMed          Journal:  Nervenarzt        ISSN: 0028-2804            Impact factor:   1.214


  9 in total

1.  Estimating national drug consumption using data at different points in the pharmaceutical supply chain.

Authors:  Michael N Cook
Journal:  Pharmacoepidemiol Drug Saf       Date:  2006-10       Impact factor: 2.890

Review 2.  Evidence of zolpidem abuse and dependence: results of the French Centre for Evaluation and Information on Pharmacodependence (CEIP) network survey.

Authors:  Caroline Victorri-Vigneau; Eric Dailly; Gwenaëlle Veyrac; Pascale Jolliet
Journal:  Br J Clin Pharmacol       Date:  2007-02-23       Impact factor: 4.335

3.  [Zolpidem: the risk of tolerance and dependence according to case reports, systematic studies and recent molecularbiological data].

Authors:  R Göder; V Treskov; J Burmester; J B Aldenhoff; D Hinze-Selch
Journal:  Fortschr Neurol Psychiatr       Date:  2001-12       Impact factor: 0.752

4.  Zolpidem dependence case series: possible neurobiological mechanisms and clinical management.

Authors:  I A Liappas; P N Malitas; N P Dimopoulos; O E Gitsa; A I Liappas; Ch K Nikolaou; G N Christodoulou
Journal:  J Psychopharmacol       Date:  2003-03       Impact factor: 4.153

5.  [A case of primary zopiclone dependence].

Authors:  I Kahlert; M Brüne
Journal:  Dtsch Med Wochenschr       Date:  2001-06-01       Impact factor: 0.628

6.  GPs' attitudes to benzodiazepine and 'Z-drug' prescribing: a barrier to implementation of evidence and guidance on hypnotics.

Authors:  A Niroshan Siriwardena; Zubair Qureshi; Steve Gibson; Sarah Collier; Martin Latham
Journal:  Br J Gen Pract       Date:  2006-12       Impact factor: 5.386

Review 7.  Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data.

Authors:  G Hajak; W E Müller; H U Wittchen; D Pittrow; W Kirch
Journal:  Addiction       Date:  2003-10       Impact factor: 6.526

8.  [High usage of zolpidem and zopiclone. Cross-sectional study using claims data].

Authors:  F Hoffmann; M Pfannkuche; G Glaeske
Journal:  Nervenarzt       Date:  2008-01       Impact factor: 1.214

9.  Update on the safety considerations in the management of insomnia with hypnotics: incorporating modified-release formulations into primary care.

Authors:  Joseph A Lieberman
Journal:  Prim Care Companion J Clin Psychiatry       Date:  2007
  9 in total
  6 in total

1.  [Insomnia in the elderly. An under-diagnosed and over-treated syndrome].

Authors:  S Schwarz; L Frölich; M Deuschle
Journal:  Internist (Berl)       Date:  2010-07       Impact factor: 0.743

2.  Hypnosedative use and predictors of successful withdrawal in new patients attending a falls clinic: a retrospective, cohort study.

Authors:  Jenna Joester; Constance M Vogler; Kevin Chang; Sarah N Hilmer
Journal:  Drugs Aging       Date:  2010-11-01       Impact factor: 3.923

3.  [Pain medication in nursing home residents with and without cancer. Most frequently with metamizole].

Authors:  J Schulze; M H Freitag; G Glaeske; G Schmiemann; F Hoffmann
Journal:  Schmerz       Date:  2015-07       Impact factor: 1.107

Review 4.  The problems of long-term treatment with benzodiazepines and related substances.

Authors:  Katrin Janhsen; Patrik Roser; Knut Hoffmann
Journal:  Dtsch Arztebl Int       Date:  2015-01-05       Impact factor: 5.594

5.  [Benzodiazepine hypnotics, zolpidem and zopiclone on private prescriptions: use between 1993 and 2012].

Authors:  F Hoffmann; G Glaeske
Journal:  Nervenarzt       Date:  2014-11       Impact factor: 1.214

6.  Eszopiclone for insomnia.

Authors:  Susanne Rösner; Christian Englbrecht; Renate Wehrle; Göran Hajak; Michael Soyka
Journal:  Cochrane Database Syst Rev       Date:  2018-10-10
  6 in total

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