Literature DB >> 1916896

Tumour necrosis factor-alpha induces translocation of protein kinase C in tumour necrosis factor-sensitive cell lines.

N Matsubara1, S Fuchimoto, K Orita.   

Abstract

In this study we investigated whether the anti-proliferative effect of tumour necrosis factor-alpha (TNF-alpha) was associated with the activation of protein kinase C (PKC), using PANC-1 cells (TNF-alpha sensitive) and LoVo cells (TNF-alpha resistant). In combination with 12-0-tetradecanoylphorbol-13-acetate (TPA), a potent activator of PKC, TNF-alpha caused marked inhibition of the growth of LoVo cells. Inhibition of PANC-1 cell growth by TNF-alpha was blocked by pretreatment with TPA for 24 hr, along with down-regulation of PKC activity. Intracellular translocation of PKC from cytosol to membrane was induced by TNF-alpha treatment in PANC-1 cells but not in LoVo cells.

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Year:  1991        PMID： 1916896      PMCID： PMC1384576     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  18 in total

1.  Tumor necrosis factor induces phosphorylation of a 28-kDa mRNA cap-binding protein in human cervical carcinoma cells.

Authors:  M W Marino; L M Pfeffer; P T Guidon; D B Donner
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

2.  An endotoxin-induced serum factor that causes necrosis of tumors.

Authors:  E A Carswell; L J Old; R L Kassel; S Green; N Fiore; B Williamson
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

3.  Differing roles of protein kinase C on the antiproliferative effects of tumor necrosis factor alpha and beta on LoVo cells.

Authors:  N Matsubara; S Fuchimoto; K Orita
Journal:  Pathobiology       Date:  1990       Impact factor: 4.342

4.  The antimitogenic action of tumor necrosis factor is associated with increased AP-1/c-jun proto-oncogene transcription.

Authors:  V M Dixit; R M Marks; V Sarma; E V Prochownik
Journal:  J Biol Chem       Date:  1989-10-05       Impact factor: 5.157

Review 5.  Cachectin and tumour necrosis factor as two sides of the same biological coin.

Authors:  B Beutler; A Cerami
Journal:  Nature       Date:  1986 Apr 17-23       Impact factor: 49.962

6.  Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha.

Authors:  D A Brenner; M O'Hara; P Angel; M Chojkier; M Karin
Journal:  Nature       Date:  1989-02-16       Impact factor: 49.962

7.  Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins.

Authors:  P Kaur; J Saklatvala
Journal:  FEBS Lett       Date:  1988-12-05       Impact factor: 4.124

8.  Interferon-gamma-induced transcriptional activation is mediated by protein kinase C.

Authors:  X D Fan; M Goldberg; B R Bloom
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

9.  Tumor necrosis factor and interleukin-1 cause a rapid and transient stimulation of c-fos and c-myc mRNA levels in human fibroblasts.

Authors:  J X Lin; J Vilcek
Journal:  J Biol Chem       Date:  1987-09-05       Impact factor: 5.157

10.  Early events in the antiproliferative action of tumor necrosis factor are similar to the early events in epidermal growth factor growth stimulation.

Authors:  N J Donato; C Ince; M G Rosenblum; G E Gallick
Journal:  J Cell Biochem       Date:  1989-11       Impact factor: 4.429
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  5 in total

1.  Gangliosides inhibit PDGF-induced signal transduction events in U-1242 MG human glioma cells.

Authors:  H E Saqr; J D Walters; Z Guan; B T Stokes; A J Yates
Journal:  Neurochem Res       Date:  1995-11       Impact factor: 3.996

2.  Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-alpha in cultured human vascular endothelial cells.

Authors:  C Patterson; M A Perrella; W O Endege; M Yoshizumi; M E Lee; E Haber
Journal:  J Clin Invest       Date:  1996-07-15       Impact factor: 14.808

3.  Differentiation of pancreatic ductal carcinoma cells associated with selective expression of protein kinase C isoforms.

Authors:  M G Franz; J G Norman; P J Fabri; W R Gower
Journal:  Ann Surg Oncol       Date:  1996-11       Impact factor: 5.344

4.  Thalidomide Promotes Morphine Efficacy and Prevents Morphine-Induced Tolerance in Rats with Diabetic Neuropathy.

Authors:  Jianhui Zhao; Hong Wang; Tieying Song; Yunliang Yang; Kunfeng Gu; Pengyu Ma; Zaiwang Zhang; Limin Shen; Jiabao Liu; Wenli Wang
Journal:  Neurochem Res       Date:  2016-08-30       Impact factor: 3.996

5.  Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation.

Authors:  A C Windsor; C J Walsh; P G Mullen; D J Cook; B J Fisher; C R Blocher; S K Leeper-Woodford; H J Sugerman; A A Fowler
Journal:  J Clin Invest       Date:  1993-04       Impact factor: 14.808
  5 in total

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