Literature DB >> 3010124

Cachectin and tumour necrosis factor as two sides of the same biological coin.

B Beutler, A Cerami.   

Abstract

In response to invasive stimuli macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

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Year:  1986        PMID： 3010124     DOI： 10.1038/320584a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  369 in total

1.  Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice.

Authors:  D Kreder; O Krut; S Adam-Klages; K Wiegmann; G Scherer; T Plitz; J M Jensen; E Proksch; J Steinmann; K Pfeffer; M Krönke
Journal:  EMBO J       Date:  1999-05-04       Impact factor: 11.598

2.  Dicer-substrate siRNA inhibits tumor necrosis factor alpha secretion in Kupffer cells in vitro: in vivo targeting of Kupffer cells by siRNA-liposomes.

Authors:  Sivakamasundari Pichu; Swapna Krishnamoorthy; Bi Zhang; Yawu Jing; Andrei Shishkov; Biddanda C Ponnappa
Journal:  Pharmacol Res       Date:  2011-09-10       Impact factor: 7.658

3.  Epidermal growth factor/TNF-α transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutrition.

Authors:  Yongjia Feng; Daniel H Teitelbaum
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2011-11-10       Impact factor: 4.052

4.  CD95 ligand expression as a mechanism of immune escape in breast cancer.

Authors:  M Müschen; C Moers; U Warskulat; J Even; D Niederacher; M W Beckmann
Journal:  Immunology       Date:  2000-01       Impact factor: 7.397

5.  Interleukin 1 promotes tumor cell adhesion to cultured human endothelial cells.

Authors:  E Dejana; F Bertocchi; M C Bortolami; A Regonesi; A Tonta; F Breviario; R Giavazzi
Journal:  J Clin Invest       Date:  1988-10       Impact factor: 14.808

6.  Recombinant human cachectin/tumor necrosis factor but not interleukin-1 alpha downregulates lipoprotein lipase gene expression at the transcriptional level in mouse 3T3-L1 adipocytes.

Authors:  R Zechner; T C Newman; B Sherry; A Cerami; J L Breslow
Journal:  Mol Cell Biol       Date:  1988-06       Impact factor: 4.272

7.  Tumour necrosis factor in synovial exudates.

Authors:  F S Di Giovine; G Nuki; G W Duff
Journal:  Ann Rheum Dis       Date:  1988-09       Impact factor: 19.103

8.  Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha.

Authors:  B Meier; H H Radeke; S Selle; M Younes; H Sies; K Resch; G G Habermehl
Journal:  Biochem J       Date:  1989-10-15       Impact factor: 3.857

9.  Human tumor necrosis factor increases the resistance against Listeria infection in mice.

Authors:  K Kato; A Nakane; T Minagawa; N Kasai; K Yamamoto; N Sato; N Tsuruoka
Journal:  Med Microbiol Immunol       Date:  1989       Impact factor: 3.402

10.  Effect of tumor necrosis factor (TNF) on lipid metabolism in the diabetic rat. Evidence that inhibition of adipose tissue lipoprotein lipase activity is not required for TNF-induced hyperlipidemia.

Authors:  K R Feingold; M Soued; I Staprans; L A Gavin; M E Donahue; B J Huang; A H Moser; R Gulli; C Grunfeld
Journal:  J Clin Invest       Date:  1989-04       Impact factor: 14.808
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