Literature DB >> 3264252

Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins.

P Kaur1, J Saklatvala.   

Abstract

Interleukin 1 (IL1) or tumour necrosis factor (TNF) stimulated phosphorylation of a triad of 27 kDa phosphoproteins (pI 6.0, 5.7 and 5.5) in human dermal fibroblasts. The change was dependent on the dose of cytokine in the range 0.1-20 ng, was detectable between 3 and 5 min after stimulation and was maximal by 10 min. The proteins were found in the cytosol after subcellular fractionation. The 32P was removed from them by alkali, indicating the presence of phosphoserine and/or phosphothreonine. The results suggest that early changes in serine/threonine protein kinase activity may be involved in responses of fibroblasts to IL1 and TNF.

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Year:  1988        PMID： 3264252     DOI： 10.1016/0014-5793(88)81019-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  16 in total

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2.  Tumor necrosis factor induces phosphorylation of a 28-kDa mRNA cap-binding protein in human cervical carcinoma cells.

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Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

3.  Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C.

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Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

4.  Interleukin-1 and synovial protein kinase C: identification of a novel, 35 kDa cytosolic substrate.

Authors:  K I Hulkower; R Sagi-Eisenberg; L M Traub; H I Georgescu; C H Evans
Journal:  Agents Actions       Date:  1991-09

5.  Ca2+ responses to interleukin 1 and tumor necrosis factor in cultured human skin fibroblasts. Possible implications for Reye syndrome.

Authors:  B E Corkey; J F Geschwind; J T Deeney; D E Hale; S D Douglas; L Kilpatrick
Journal:  J Clin Invest       Date:  1991-03       Impact factor: 14.808

6.  Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669.

Authors:  M Kracht; M Shiroo; C J Marshall; J J Hsuan; J Saklatvala
Journal:  Biochem J       Date:  1994-09-15       Impact factor: 3.857

7.  Interleukin 1 beta induces rapid phosphorylation and redistribution of talin: a possible mechanism for modulation of fibroblast focal adhesion.

Authors:  E E Qwarnström; S A MacFarlane; R C Page; S K Dower
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-15       Impact factor: 11.205

8.  Phosphorylation of the small heat-shock protein is regulated by interleukin 1, tumour necrosis factor, growth factors, bradykinin and ATP.

Authors:  J Saklatvala; P Kaur; F Guesdon
Journal:  Biochem J       Date:  1991-08-01       Impact factor: 3.857

9.  Tumour necrosis factor-alpha induces translocation of protein kinase C in tumour necrosis factor-sensitive cell lines.

Authors:  N Matsubara; S Fuchimoto; K Orita
Journal:  Immunology       Date:  1991-08       Impact factor: 7.397

10.  The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.

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Journal:  Biochem J       Date:  1993-12-15       Impact factor: 3.857
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