Literature DB >> 19165896

Structural studies of conotoxins.

Norelle L Daly1, David J Craik.   

Abstract

Conotoxins are small disulfide-rich peptides from the venoms of marine cone snails. They target a variety of ion channels, transporters, and receptors besides the interest in their natural functions in venoms and they are of much interest as drug leads. This short article gives an overview of the structural diversity of conotoxins, and illustrates this diversity with recent selected examples of conotoxin structures.

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Year:  2009        PMID: 19165896     DOI: 10.1002/iub.158

Source DB:  PubMed          Journal:  IUBMB Life        ISSN: 1521-6543            Impact factor:   3.885


  14 in total

Review 1.  Targeting voltage-gated calcium channels: developments in peptide and small-molecule inhibitors for the treatment of neuropathic pain.

Authors:  S Vink; P F Alewood
Journal:  Br J Pharmacol       Date:  2012-11       Impact factor: 8.739

2.  Molecular phylogeny, classification and evolution of conopeptides.

Authors:  N Puillandre; D Koua; P Favreau; B M Olivera; R Stöcklin
Journal:  J Mol Evol       Date:  2012-07-04       Impact factor: 2.395

3.  Diversity of conotoxin types from Conus californicus reflects a diversity of prey types and a novel evolutionary history.

Authors:  C A Elliger; T A Richmond; Z N Lebaric; N T Pierce; J V Sweedler; W F Gilly
Journal:  Toxicon       Date:  2010-12-21       Impact factor: 3.033

Review 4.  NMR and protein structure in drug design: application to cyclotides and conotoxins.

Authors:  Norelle L Daly; K Johan Rosengren; Sónia Troeira Henriques; David J Craik
Journal:  Eur Biophys J       Date:  2011-02-03       Impact factor: 1.733

Review 5.  Analgesic conotoxins: block and G protein-coupled receptor modulation of N-type (Ca(V) 2.2) calcium channels.

Authors:  David J Adams; Brid Callaghan; Géza Berecki
Journal:  Br J Pharmacol       Date:  2012-05       Impact factor: 8.739

6.  Human β-defensin 4 with non-native disulfide bridges exhibit antimicrobial activity.

Authors:  Himanshu Sharma; Ramakrishnan Nagaraj
Journal:  PLoS One       Date:  2015-03-18       Impact factor: 3.240

Review 7.  Discovery, synthesis, and structure-activity relationships of conotoxins.

Authors:  Kalyana B Akondi; Markus Muttenthaler; Sébastien Dutertre; Quentin Kaas; David J Craik; Richard J Lewis; Paul F Alewood
Journal:  Chem Rev       Date:  2014-04-10       Impact factor: 60.622

8.  Mining the Royal Jelly Proteins: Combinatorial Hexapeptide Ligand Library Significantly Improves the MS-Based Proteomic Identification in Complex Biological Samples.

Authors:  Eliza Matuszewska; Joanna Matysiak; Grzegorz Rosiński; Elżbieta Kędzia; Weronika Ząbek; Jarosław Zawadziński; Jan Matysiak
Journal:  Molecules       Date:  2021-05-07       Impact factor: 4.411

9.  A novel inhibitor of α9α10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily.

Authors:  Sulan Luo; Sean Christensen; Dongting Zhangsun; Yong Wu; Yuanyan Hu; Xiaopeng Zhu; Sandeep Chhabra; Raymond S Norton; J Michael McIntosh
Journal:  PLoS One       Date:  2013-01-30       Impact factor: 3.240

10.  iCTX-type: a sequence-based predictor for identifying the types of conotoxins in targeting ion channels.

Authors:  Hui Ding; En-Ze Deng; Lu-Feng Yuan; Li Liu; Hao Lin; Wei Chen; Kuo-Chen Chou
Journal:  Biomed Res Int       Date:  2014-06-01       Impact factor: 3.411

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