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Literature DB >> 19161168

Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain.

Jens H Jensen¹, Kamila Szulc, Caixia Hu, Anita Ramani, Hanzhang Lu, Liang Xuan, Maria F Falangola, Ramesh Chandra, Edmond A Knopp, John Schenck, Earl A Zimmerman, Joseph A Helpern.

Abstract

The magnetic field correlation (MFC) at an applied field level of 3 Tesla was estimated by means of MRI in several brain regions for 21 healthy human adults and 1 subject with aceruloplasminemia. For healthy subjects, highly elevated MFC values compared with surrounding tissues were found within the basal ganglia. These are argued as being primarily the result of microscopic magnetic field inhomogeneities generated by nonheme brain iron. The MFC in the aceruloplasminemia subject was significantly higher than for healthy adults in the globus pallidus, thalamus and frontal white matter, consistent with the known increased brain iron concentration associated with this disease. Copyright 2009 Wiley-Liss, Inc.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Iron

Year: 2009 PMID： 19161168 PMCID： PMC2632731 DOI： 10.1002/mrm.21823

Source DB: PubMed Journal: Magn Reson Med ISSN： 0740-3194 Impact factor: 4.668

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