| Literature DB >> 19153998 |
Elena V Dementyeva1, Alexander I Shevchenko, Suren M Zakian.
Abstract
Mammals have a very complex, tightly controlled, and developmentally regulated process of dosage compensation. One form of the process equalizes expression of the X-linked genes, present as a single copy in males (XY) and as two copies in females (XX), by inactivation of one of the two X-chromosomes in females. The second form of the process leads to balanced expression between the X-linked and autosomal genes by transcriptional upregulation of the active X in males and females. However, not all X-linked genes are absolutely balanced. This review is focused on the recent advances in studying the dosage compensation phenomenon in mammals.Mesh:
Year: 2009 PMID: 19153998 DOI: 10.1002/bies.080149
Source DB: PubMed Journal: Bioessays ISSN: 0265-9247 Impact factor: 4.345