Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

Literature DB >> 1915266

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

D P Gearing¹, C J Thut, T VandeBos, S D Gimpel, P B Delaney, J King, V Price, D Cosman, M P Beckmann.

Abstract

Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin-6 (IL-6) although LIF and IL-6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 'signal-transducing' component of the IL-6 receptor and to the G-CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross-hybridization and share 70% amino acid sequence identity to the human sequence.

Entities: Chemical

Mesh：

Substances：

Year: 1991 PMID： 1915266 PMCID： PMC452994 DOI： 10.1002/j.1460-2075.1991.tb07833.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

65 in total

1. A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain.

Authors: J F Bazan
Journal: Biochem Biophys Res Commun Date: 1989-10-31 Impact factor: 3.575

2. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130.

Authors: T Taga; M Hibi; Y Hirata; K Yamasaki; K Yasukawa; T Matsuda; T Hirano; T Kishimoto
Journal: Cell Date: 1989-08-11 Impact factor: 41.582

3. Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice.

Authors: D Metcalf; N A Nicola; D P Gearing
Journal: Blood Date: 1990-07-01 Impact factor: 22.113

4. Clonal suppression of HL60 and U937 cells by recombinant human leukemia inhibitory factor in combination with GM-CSF or G-CSF.

Authors: T Maekawa; D Metcalf
Journal: Leukemia Date: 1989-04 Impact factor: 11.528

5. Expression, purification and characterization of recombinant murine granulocyte-macrophage colony-stimulating factor and bovine interleukin-2 from yeast.

Authors: V Price; D Mochizuki; C J March; D Cosman; M C Deeley; R Klinke; W Clevenger; S Gillis; P Baker; D Urdal
Journal: Gene Date: 1987 Impact factor: 3.688

6. The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms.

Authors: B Mosley; M P Beckmann; C J March; R L Idzerda; S D Gimpel; T VandenBos; D Friend; A Alpert; D Anderson; J Jackson
Journal: Cell Date: 1989-10-20 Impact factor: 41.582

7. Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.

Authors: K Yamasaki; T Taga; Y Hirata; H Yawata; Y Kawanishi; B Seed; T Taniguchi; T Hirano; T Kishimoto
Journal: Science Date: 1988-08-12 Impact factor: 47.728

8. Characterization of the high-affinity cell-surface receptor for murine B-cell-stimulating factor 1.

Authors: L S Park; D Friend; K Grabstein; D L Urdal
Journal: Proc Natl Acad Sci U S A Date: 1987-03 Impact factor: 11.205

9. Clonal analysis of the actions of the murine leukemia inhibitory factor on leukemic and normal murine hemopoietic cells.

Authors: D Metcalf; D J Hilton; N A Nicola
Journal: Leukemia Date: 1988-04 Impact factor: 11.528

10. Molecular cloning and expression of the murine interleukin-5 receptor.

Authors: S Takaki; A Tominaga; Y Hitoshi; S Mita; E Sonoda; N Yamaguchi; K Takatsu
Journal: EMBO J Date: 1990-12 Impact factor: 11.598

124 in total

Review 1. Receptor recognition by gp130 cytokines.

Authors: J Bravo; J K Heath
Journal: EMBO J Date: 2000-06-01 Impact factor: 11.598

2. Evidence for the formation of a heterotrimeric complex of leukaemia inhibitory factor with its receptor subunits in solution.

Authors: J G Zhang; C M Owczarek; L D Ward; G J Howlett; L J Fabri; B A Roberts; N A Nicola
Journal: Biochem J Date: 1997-08-01 Impact factor: 3.857

3. Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.

Authors: T Taga; M Narazaki; K Yasukawa; T Saito; D Miki; M Hamaguchi; S Davis; M Shoyab; G D Yancopoulos; T Kishimoto
Journal: Proc Natl Acad Sci U S A Date: 1992-11-15 Impact factor: 11.205

4. Epigenetic Interactions and Gene Expression in Peri-Implantation Mouse Embryo Development.

Authors: Jean J Latimer; Roger A Pedersen
Journal: Mod Cell Biol Date: 1993

Review 5. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.

Authors: P C Heinrich; I Behrmann; G Müller-Newen; F Schaper; L Graeve
Journal: Biochem J Date: 1998-09-01 Impact factor: 3.857

6. Oncostatin-M stimulates tyrosine protein phosphorylation in parallel with the activation of p42MAPK/ERK-2 in Kaposi's cells. Evidence that this pathway is important in Kaposi cell growth.

Authors: M C Amaral; S Miles; G Kumar; A E Nel
Journal: J Clin Invest Date: 1993-08 Impact factor: 14.808

7. Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction.

Authors: S F Ziegler; T A Bird; K K Morella; B Mosley; D P Gearing; H Baumann
Journal: Mol Cell Biol Date: 1993-04 Impact factor: 4.272