| Literature DB >> 19151714 |
David Meyre1, Jérôme Delplanque, Jean-Claude Chèvre, Cécile Lecoeur, Stéphane Lobbens, Sophie Gallina, Emmanuelle Durand, Vincent Vatin, Franck Degraeve, Christine Proença, Stefan Gaget, Antje Körner, Peter Kovacs, Wieland Kiess, Jean Tichet, Michel Marre, Anna-Liisa Hartikainen, Fritz Horber, Natascha Potoczna, Serge Hercberg, Claire Levy-Marchal, François Pattou, Barbara Heude, Maithé Tauber, Mark I McCarthy, Alexandra I F Blakemore, Alexandre Montpetit, Constantin Polychronakos, Jacques Weill, Lachlan J M Coin, Julian Asher, Paul Elliott, Marjo-Riitta Järvelin, Sophie Visvikis-Siest, Beverley Balkau, Rob Sladek, David Balding, Andrew Walley, Christian Dina, Philippe Froguel.
Abstract
We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).Entities:
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Year: 2009 PMID： 19151714 DOI： 10.1038/ng.301
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330