Literature DB >> 19149665

Prodrug designing of NSAIDs.

Parmeshwari K Halen1, Prashant R Murumkar, Rajani Giridhar, Mange Ram Yadav.   

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflammatory diseases suffer from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The prodrug designing is one of the several strategies used to overcome this drawback. The rationale behind the prodrug concept is to achieve temporary blockade of the free carboxylic group present in the NSAIDs till their systemic absorption. In this paper, a review on the concept of prodrugs designing of NSAIDs to improve their efficacy and reduce the toxicity is being presented.

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Year:  2009        PMID： 19149665     DOI： 10.2174/138955709787001695

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  13 in total

1.  Exploring hydrogen peroxide responsive thiazolidinone-based prodrugs.

Authors:  Christian Perez; Jean-Philippe Monserrat; Yao Chen; Seth M Cohen
Journal:  Chem Commun (Camb)       Date:  2015-04-28       Impact factor: 6.222

2.  Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity.

Authors:  Chi C Wong; Ka-Wing Cheng; Gang Xie; Dingying Zhou; Cai-Hua Zhu; Panayiotis P Constantinides; Basil Rigas
Journal:  J Pharmacol Exp Ther       Date:  2011-11-15       Impact factor: 4.030

3.  Evaluation of diclofenac prodrugs for enhancing transdermal delivery.

Authors:  Shabbir Lobo; Henan Li; Nashid Farhan; Guang Yan
Journal:  Drug Dev Ind Pharm       Date:  2013-04-23       Impact factor: 3.225

4.  Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.

Authors:  Mohamed F Radwan; Kevin N Dalby; Tamer S Kaoud
Journal:  ACS Med Chem Lett       Date:  2014-06-23       Impact factor: 4.345

5.  N'-[(E)-(Furan-2-yl)methyl-idene]-2-[4-(2-methyl-prop-yl)phen-yl]propano-hydrazide.

Authors:  Mehmet Akkurt; Shaaban K Mohamed; Joel T Mague; Mustafa R Albayati; Sabry H H Younes
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-02-26

6.  N'-[(E)-4-Meth-oxy-benzyl-idene]-2-(5-meth-oxy-2-methyl-1H-indol-3-yl)acetohydrazide.

Authors:  Mehmet Akkurt; Joel T Mague; Shaaban K Mohamed; Antar A Abelhamid; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-10-19

7.  Anti-inflammatory agents of the carbamoylmethyl ester class: synthesis, characterization, and pharmacological evaluation.

Authors:  Bassem Sadek; Amar Mansuor Hamruoni; Abdu Adem
Journal:  J Inflamm Res       Date:  2013-03-03

Review 8.  Prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs), more than meets the eye: a critical review.

Authors:  Amjad M Qandil
Journal:  Int J Mol Sci       Date:  2012-12-17       Impact factor: 5.923

9.  Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect.

Authors:  Jean Leandro Dos Santos; Vanessa Moreira; Michel Leandro Campos; Rafael Consolin Chelucci; Karina Pereira Barbieri; Pollyana Cristina Maggio de Castro Souto; Márcio Hideki Matsubara; Catarina Teixeira; Priscila Longhin Bosquesi; Rosângela Gonçalves Peccinini; Chung Man Chin
Journal:  Int J Mol Sci       Date:  2012-11-19       Impact factor: 5.923

10.  2-(5-Meth-oxy-2-methyl-1H-indol-3-yl)-N'-[(1E,2E)-3-phenyl-prop-2-en-1-yl-idene]acetohydrazide.

Authors:  Mehmet Akkurt; Joel T Mague; Shaaban K Mohamed; Mustafa R Albayati; Mahmoud A A El-Remaily
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-08-31
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