OBJECTIVE: Younger, but not older, women have a higher mortality than men of similar age after a myocardial infarction (MI). We sought to determine whether this relationship is true for both ST elevation MI (STEMI) and non-ST elevation MI (NSTEMI). DESIGN: Retrospective cohort study. SETTING: 1057 USA hospitals participant in the National Registry of Myocardial Infarction between 2000 and 2006. PATIENTS: 126 172 STEMI and 235 257 NSTEMI patients. MAIN OUTCOME MEASURE: Hospital death. RESULTS: For both STEMI and NSTEMI, the younger the patient's age, the greater the excess mortality risk for women compared with men, while older women fared similarly (STEMI) or better (NSTEMI) than men (p<0.0001 for the age-sex interaction). In STEMI, the unadjusted women-to-men RR was 1.68 (95% CI 1.41 to 2.01), 1.78 (1.59 to 1.99), 1.45 (1.34 to 1.57), 1.08 (1.02 to 1.14) and 1.03 (0.98 to 1.07) for age <50 years, age 50-59, age 60-69, age 70-79 and age 80-89, respectively. For NSTEMI, corresponding unadjusted RRs were 1.56 (1.31 to 1.85), 1.42 (1.27 to 1.58), 1.17 (1.09 to 1.25), 0.92 (0.88 to 0.96) and 0.86 (0.83 to 0.89). After adjusting for risk status, the excess risk for younger women compared with men decreased to approximately 15-20%, while a better survival of older NSTEMI women compared with men persisted. CONCLUSIONS: Sex-related differences in short-term mortality are age-dependent in both STEMI and NSTEMI patients.
OBJECTIVE: Younger, but not older, women have a higher mortality than men of similar age after a myocardial infarction (MI). We sought to determine whether this relationship is true for both ST elevation MI (STEMI) and non-ST elevation MI (NSTEMI). DESIGN: Retrospective cohort study. SETTING: 1057 USA hospitals participant in the National Registry of Myocardial Infarction between 2000 and 2006. PATIENTS: 126 172 STEMI and 235 257 NSTEMI patients. MAIN OUTCOME MEASURE: Hospital death. RESULTS: For both STEMI and NSTEMI, the younger the patient's age, the greater the excess mortality risk for women compared with men, while older women fared similarly (STEMI) or better (NSTEMI) than men (p<0.0001 for the age-sex interaction). In STEMI, the unadjusted women-to-men RR was 1.68 (95% CI 1.41 to 2.01), 1.78 (1.59 to 1.99), 1.45 (1.34 to 1.57), 1.08 (1.02 to 1.14) and 1.03 (0.98 to 1.07) for age <50 years, age 50-59, age 60-69, age 70-79 and age 80-89, respectively. For NSTEMI, corresponding unadjusted RRs were 1.56 (1.31 to 1.85), 1.42 (1.27 to 1.58), 1.17 (1.09 to 1.25), 0.92 (0.88 to 0.96) and 0.86 (0.83 to 0.89). After adjusting for risk status, the excess risk for younger women compared with men decreased to approximately 15-20%, while a better survival of older NSTEMI women compared with men persisted. CONCLUSIONS: Sex-related differences in short-term mortality are age-dependent in both STEMI and NSTEMI patients.
Authors: George K Andrikopoulos; Stylianos E Tzeis; Athanasios G Pipilis; Dimitri J Richter; Konstantinos G Kappos; Christodoulos I Stefanadis; Pavlos K Toutouzas; Elias T Chimonas Journal: Int J Cardiol Date: 2005-06-15 Impact factor: 4.164
Authors: J S Hochman; J E Tamis; T D Thompson; W D Weaver; H D White; F Van de Werf; P Aylward; E J Topol; R M Califf Journal: N Engl J Med Date: 1999-07-22 Impact factor: 91.245
Authors: V Vaccarino; H M Krumholz; C F Mendes de Leon; T R Holford; T E Seeman; R I Horwitz; L F Berkman Journal: J Am Geriatr Soc Date: 1996-10 Impact factor: 5.562
Authors: Jessica L Mega; David A Morrow; Erika Ostör; Maria Dorobantu; Jie Qin; Elliott M Antman; Eugene Braunwald Journal: Circulation Date: 2007-05-21 Impact factor: 29.690
Authors: Manal Alasnag; Alexander G Truesdell; Holli Williams; Sara C Martinez; Syeda Kashfi Qadri; John P Skendelas; William A Jakobleff; Mirvat Alasnag Journal: Curr Atheroscler Rep Date: 2020-04-23 Impact factor: 5.113
Authors: Alice M Jackson; Ruiqi Zhang; Iain Findlay; Keith Robertson; Mitchell Lindsay; Tamsin Morris; Brian Forbes; Richard Papworth; Alex McConnachie; Kenneth Mangion; Pardeep S Jhund; Colin McCowan; Colin Berry Journal: Eur Heart J Qual Care Clin Outcomes Date: 2020-04-01
Authors: Petra Hillinger; Raphael Twerenbold; Karin Wildi; Maria Rubini Gimenez; Cedric Jaeger; Jasper Boeddinghaus; Thomas Nestelberger; Karin Grimm; Tobias Reichlin; Fabio Stallone; Christian Puelacher; Zaid Sabti; Nikola Kozhuharov; Ursina Honegger; Paola Ballarino; Oscar Miro; Kris Denhaerynck; Temizel Ekrem; Claudia Kohler; Roland Bingisser; Stefan Osswald; Christian Mueller Journal: Clin Res Cardiol Date: 2016-07-12 Impact factor: 5.460
Authors: Erica C Leifheit-Limson; Gail D'Onofrio; Mitra Daneshvar; Mary Geda; Héctor Bueno; John A Spertus; Harlan M Krumholz; Judith H Lichtman Journal: J Am Coll Cardiol Date: 2015-11-03 Impact factor: 24.094
Authors: Emily M Bucholz; Kelly M Strait; Rachel P Dreyer; Stacy T Lindau; Gail D'Onofrio; Mary Geda; Erica S Spatz; John F Beltrame; Judith H Lichtman; Nancy P Lorenze; Hector Bueno; Harlan M Krumholz Journal: Eur Heart J Acute Cardiovasc Care Date: 2016-08-02
Authors: Amber M Otten; Angela H E M Maas; Jan Paul Ottervanger; Anita Kloosterman; Arnoud W J van 't Hof; Jan Henk E Dambrink; A T Marcel Gosselink; Jan C A Hoorntje; Harry Suryapranata; Menko Jan de Boer Journal: Eur Heart J Acute Cardiovasc Care Date: 2013-01-31