Literature DB >> 19147549

On the role of cell signaling models in cancer research.

Alejandra C Ventura1, Trachette L Jackson, Sofia D Merajver.   

Abstract

The main objective of this review is to emphasize the role and importance of the careful mathematical/computational modeling of signaling networks for the understanding of aberrant signaling in cancer and for the development of targeted therapies.

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Mesh：

Year:  2009        PMID： 19147549      PMCID： PMC4349517          DOI： 10.1158/0008-5472.CAN-08-4422

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  13 in total

Review 1.  Bioengineering models of cell signaling.

Authors:  A R Asthagiri; D A Lauffenburger
Journal:  Annu Rev Biomed Eng       Date:  2000       Impact factor: 9.590

2.  Mathematical models of protein kinase signal transduction.

Authors:  Reinhart Heinrich; Benjamin G Neel; Tom A Rapoport
Journal:  Mol Cell       Date:  2002-05       Impact factor: 17.970

3.  Complexity in biological signaling systems.

Authors:  G Weng; U S Bhalla; R Iyengar
Journal:  Science       Date:  1999-04-02       Impact factor: 47.728

4.  Bistability in cell signaling: How to make continuous processes discontinuous, and reversible processes irreversible.

Authors:  James E. Ferrell; Wen Xiong
Journal:  Chaos       Date:  2001-03       Impact factor: 3.642

Review 5.  Cell-signalling dynamics in time and space.

Authors:  Boris N Kholodenko
Journal:  Nat Rev Mol Cell Biol       Date:  2006-03       Impact factor: 94.444

6.  A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase.

Authors:  A Goldbeter
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

7.  An amplified sensitivity arising from covalent modification in biological systems.

Authors:  A Goldbeter; D E Koshland
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

8.  Modeling the VEGF-Bcl-2-CXCL8 pathway in intratumoral agiogenesis.

Authors:  Harsh V Jain; Jacques E Nör; Trachette L Jackson
Journal:  Bull Math Biol       Date:  2007-08-16       Impact factor: 1.758

9.  Modeling the septation initiation network (SIN) in fission yeast cells.

Authors:  Attila Csikász-Nagy; Orsolya Kapuy; Béla Gyorffy; John J Tyson; Béla Novák
Journal:  Curr Genet       Date:  2007-03-06       Impact factor: 2.695

10.  A hidden feedback in signaling cascades is revealed.

Authors:  Alejandra C Ventura; Jacques-A Sepulchre; Sofía D Merajver
Journal:  PLoS Comput Biol       Date:  2008-03-21       Impact factor: 4.475
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  14 in total

1.  Long signaling cascades tend to attenuate retroactivity.

Authors:  Hamid R Ossareh; Alejandra C Ventura; Sofia D Merajver; Domitilla Del Vecchio
Journal:  Biophys J       Date:  2011-04-06       Impact factor: 4.033

Review 2.  Physical oncology: a bench-to-bedside quantitative and predictive approach.

Authors:  Hermann B Frieboes; Mark A J Chaplain; Alastair M Thompson; Elaine L Bearer; John S Lowengrub; Vittorio Cristini
Journal:  Cancer Res       Date:  2011-01-11       Impact factor: 12.701

3.  Nonlinear modelling of cancer: bridging the gap between cells and tumours.

Authors:  J S Lowengrub; H B Frieboes; F Jin; Y-L Chuang; X Li; P Macklin; S M Wise; V Cristini
Journal:  Nonlinearity       Date:  2010

4.  Predictions of tumour morphological stability and evaluation against experimental observations.

Authors:  Kara Pham; Hermann B Frieboes; Vittorio Cristini; John Lowengrub
Journal:  J R Soc Interface       Date:  2010-06-02       Impact factor: 4.118

5.  Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.

Authors:  Greg M Thurber; Katy S Yang; Thomas Reiner; Rainer H Kohler; Peter Sorger; Tim Mitchison; Ralph Weissleder
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

6.  Integrated experimental and model-based analysis reveals the spatial aspects of EGFR activation dynamics.

Authors:  Harish Shankaran; Yi Zhang; William B Chrisler; Jonathan A Ewald; H Steven Wiley; Haluk Resat
Journal:  Mol Biosyst       Date:  2012-09-05

7.  Exploiting clinical trial data drastically narrows the window of possible solutions to the problem of clinical adaptation of a multiscale cancer model.

Authors:  Georgios S Stamatakos; Eleni C Georgiadi; Norbert Graf; Eleni A Kolokotroni; Dimitra D Dionysiou
Journal:  PLoS One       Date:  2011-03-03       Impact factor: 3.240

8.  Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors.

Authors:  Anne L van de Ven; Min Wu; John Lowengrub; Steven R McDougall; Mark A J Chaplain; Vittorio Cristini; Mauro Ferrari; Hermann B Frieboes
Journal:  AIP Adv       Date:  2012-03-22       Impact factor: 1.548

9.  Dealing with diversity in computational cancer modeling.

Authors:  David Johnson; Steve McKeever; Georgios Stamatakos; Dimitra Dionysiou; Norbert Graf; Vangelis Sakkalis; Konstantinos Marias; Zhihui Wang; Thomas S Deisboeck
Journal:  Cancer Inform       Date:  2013-05-07

10.  An integrated computational/experimental model of lymphoma growth.

Authors:  Hermann B Frieboes; Bryan R Smith; Yao-Li Chuang; Ken Ito; Allison M Roettgers; Sanjiv S Gambhir; Vittorio Cristini
Journal:  PLoS Comput Biol       Date:  2013-03-28       Impact factor: 4.475
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