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Literature DB >> 10102825

Complexity in biological signaling systems.

Abstract

Biological signaling pathways interact with one another to form complex networks. Complexity arises from the large number of components, many with isoforms that have partially overlapping functions; from the connections among components; and from the spatial relationship between components. The origins of the complex behavior of signaling networks and analytical approaches to deal with the emergent complexity are discussed here.

Mesh：

Substances：
GTP-Binding Proteins

Year: 1999 PMID： 10102825 PMCID： PMC3773983 DOI： 10.1126/science.284.5411.92

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

25 in total

Review 1. Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism.

Authors: A Destexhe; Z F Mainen; T J Sejnowski
Journal: J Comput Neurosci Date: 1994-08 Impact factor: 1.621

2. Emergent properties of networks of biological signaling pathways.

Authors: U S Bhalla; R Iyengar
Journal: Science Date: 1999-01-15 Impact factor: 47.728

3. Excitation, oscillations and wave propagation in a G-protein-based model of signal transduction in Dictyostelium discoideum.

Authors: Y Tang; H G Othmer
Journal: Philos Trans R Soc Lond B Biol Sci Date: 1995-08-29 Impact factor: 6.237

4. Computing with cyclic AMP.

Authors: E Marder
Journal: Nature Date: 1996-11-14 Impact factor: 49.962

5. Adenosine receptor permanently coupled to turkey erythrocyte adenylate cyclase.

Authors: S Braun; A Levitzki
Journal: Biochemistry Date: 1979-05-15 Impact factor: 3.162

6. Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model.

Authors: L Birnbaumer; T L Swartz; J Abramowitz; P W Mintz; R Iyengar
Journal: J Biol Chem Date: 1980-04-25 Impact factor: 5.157

8. Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups.

Authors: Jason M Haugh; Ian C Schneider
Journal: Biophys J Date: 2004-01 Impact factor: 4.033

Review 9. Archaeal protein kinases and protein phosphatases: insights from genomics and biochemistry.

Authors: Peter J Kennelly
Journal: Biochem J Date: 2003-03-01 Impact factor: 3.857

Review 10. Modeling cell signaling networks.

Authors: Narat J Eungdamrong; Ravi Iyengar
Journal: Biol Cell Date: 2004-06 Impact factor: 4.458

Complexity in biological signaling systems.

Review 1. Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism.

2. Emergent properties of networks of biological signaling pathways.

3. Excitation, oscillations and wave propagation in a G-protein-based model of signal transduction in Dictyostelium discoideum.

4. Computing with cyclic AMP.

5. Adenosine receptor permanently coupled to turkey erythrocyte adenylate cyclase.

6. Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model.

Review 7. Combinatorial approaches to polyketide biosynthesis.

8. A mammalian scaffold complex that selectively mediates MAP kinase activation.

9. GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors.

10. Ultrasensitivity in the mitogen-activated protein kinase cascade.

1. The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities.

2. Isoform-specific localization of A-RAF in mitochondria.

3. A unified model for signal transduction reactions in cellular membranes.

Review 4. Nonlinear dynamics and chaos theory: concepts and applications relevant to pharmacodynamics.

5. Chromosomal variation in neurons of the developing and adult mammalian nervous system.

Review 6. Degeneracy and complexity in biological systems.

7. Heparin sequencing brings structure to the function of complex oligosaccharides.

8. Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups.

Review 9. Archaeal protein kinases and protein phosphatases: insights from genomics and biochemistry.

Review 10. Modeling cell signaling networks.