Literature DB >> 19139285

Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells.

Ruth A Bryan1, Zewei Jiang, Xianchun Huang, Alfred Morgenstern, Frank Bruchertseifer, Rani Sellers, Arturo Casadevall, Ekaterina Dadachova.   

Abstract

We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.

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Year:  2009        PMID： 19139285      PMCID： PMC2663079          DOI： 10.1128/AAC.01334-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Production of Ac-225 from Th-229 for targeted alpha therapy.

Authors:  C Apostolidis; R Molinet; G Rasmussen; A Morgenstern
Journal:  Anal Chem       Date:  2005-10-01       Impact factor: 6.986

2.  Interaction of radiolabeled antibodies with fungal cells and components of the immune system in vitro and during radioimmunotherapy for experimental fungal infection.

Authors:  Ekaterina Dadachova; Ruth A Bryan; Christos Apostolidis; Alfred Morgenstern; Tong Zhang; Tiffany Moadel; Marcela Torres; Xianchun Huang; Ekaterina Revskaya; Arturo Casadevall
Journal:  J Infect Dis       Date:  2006-04-13       Impact factor: 5.226

3.  Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans.

Authors:  Ruth A Bryan; Xianchun Huang; Alfred Morgenstern; Frank Bruchertseifer; Arturo Casadevall; Ekaterina Dadachova
Journal:  Antimicrob Agents Chemother       Date:  2008-03-31       Impact factor: 5.191

4.  Antibodies elicited by a Cryptococcus neoformans-tetanus toxoid conjugate vaccine have the same specificity as those elicited in infection.

Authors:  A Casadevall; J Mukherjee; S J Devi; R Schneerson; J B Robbins; M D Scharff
Journal:  J Infect Dis       Date:  1992-06       Impact factor: 5.226

5.  Ionizing radiation delivered by specific antibody is therapeutic against a fungal infection.

Authors:  Ekaterina Dadachova; Antonio Nakouzi; Ruth A Bryan; Arturo Casadevall
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-20       Impact factor: 11.205

6.  Genetic control of susceptibility to Cryptococcus neoformans in mice.

Authors:  J C Rhodes; L S Wicker; W J Urba
Journal:  Infect Immun       Date:  1980-08       Impact factor: 3.441

Review 7.  Host and microbial cells as targets for armed antibodies in the treatment of infectious diseases.

Authors:  Ekaterina Dadachova; Arturo Casadevall
Journal:  Curr Opin Investig Drugs       Date:  2008-02

8.  Evaluation of acute hematologic and long-term pulmonary toxicities of radioimmunotherapy of Cryptococcus neoformans infection in murine models.

Authors:  E Dadachova; R A Bryan; A Frenkel; T Zhang; C Apostolidis; J S Nosanchuk; J D Nosanchuk; A Casadevall
Journal:  Antimicrob Agents Chemother       Date:  2004-03       Impact factor: 5.191

9.  Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins.

Authors:  Ekaterina Dadachova; Mahesh C Patel; Sima Toussi; Christos Apostolidis; Alfred Morgenstern; Martin W Brechbiel; Miroslaw K Gorny; Susan Zolla-Pazner; Arturo Casadevall; Harris Goldstein
Journal:  PLoS Med       Date:  2006-11       Impact factor: 11.069
  9 in total
  7 in total

1.  Treatment of early and established Cryptococcus neoformans infection with radiolabeled antibodies in immunocompetent mice.

Authors:  Zewei Jiang; Ruth A Bryan; Alfred Morgenstern; Frank Bruchertseifer; Arturo Casadevall; Ekaterina Dadachova
Journal:  Antimicrob Agents Chemother       Date:  2011-10-17       Impact factor: 5.191

2.  Radioimmunotherapy of Cryptococcus neoformans spares bystander mammalian cells.

Authors:  Ruth A Bryan; Zewei Jiang; Alfred Morgenstern; Frank Bruchertseifer; Arturo Casadevall; Ekaterina Dadachova
Journal:  Future Microbiol       Date:  2013-09       Impact factor: 3.165

3.  Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection.

Authors:  Ruth A Bryan; Zewei Jiang; Robertha C Howell; Alfred Morgenstern; Frank Bruchertseifer; Arturo Casadevall; Ekaterina Dadachova
Journal:  J Infect Dis       Date:  2010-08-15       Impact factor: 5.226

4.  Radiolabeled antibodies for therapy of infectious diseases.

Authors:  Ekaterina Dadachova; Arturo Casadevall
Journal:  Microbiol Spectr       Date:  2014-11

Review 5.  Cancer radioimmunotherapy.

Authors:  Robert M Sharkey; David M Goldenberg
Journal:  Immunotherapy       Date:  2011-03       Impact factor: 4.196

6.  Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections.

Authors:  Ekaterina Dadachova; Arturo Casadevall
Journal:  Interdiscip Perspect Infect Dis       Date:  2011-05-24

7.  Radioimmunotherapy of fungal diseases: the therapeutic potential of cytocidal radiation delivered by antibody targeting fungal cell surface antigens.

Authors:  Joshua D Nosanchuk; Ekaterina Dadachova
Journal:  Front Microbiol       Date:  2012-01-12       Impact factor: 5.640
  7 in total

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