| Literature DB >> 19138654 |
Kiyoshi Migita1, Kazumi Sawakami-Kobayashi, Yumi Maeda, Kazuhiko Nakao, Susumu Kondoh, Mika Sugiura, Ryoko Kawasumi, Osamu Segawa, Hideji Tajima, Masayuki Machida, Minoru Nakamura, Koji Yano, Seigo Abiru, Eiji Kawasaki, Hiroshi Yatsuhashi, Katsumi Eguchi, Hiromi Ishibashi.
Abstract
In this study, we aimed to explore whether interleukin-18 (IL-18) gene-promoter polymorphisms are associated with the outcome of hepatitis B virus (HBV) infection. In all, 204 chronically HBV-infected patients were recruited in this study. Of the 204 HBV-infected patients, 43 were considered to be inactive HBV carriers based on the sustained normalization of serum alanine aminotransferase (ALT) together with seropositivity for the antibody to hepatitis B e-antigen (anti-HBe). A total of 161 patients were found to have chronic progressive liver disease, which included cirrhosis. In these HBV-infected patients, the frequencies of AA genotype of IL-18 gene-promoter polymorphisms at position -607 and C allele at position -137 were significantly higher in inactive HBV carriers compared with those in patients with chronic progressive liver disease. These polymorphisms of the IL-18 promoter regions (-607 and -137) could be associated with different outcomes of HBV infection.Entities:
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Year: 2008 PMID： 19138654 DOI： 10.1016/j.trsl.2008.11.008
Source DB: PubMed Journal: Transl Res ISSN： 1878-1810 Impact factor: 7.012