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Literature DB >> 19136973

Neuronal release of proBDNF.

Jianmin Yang¹, Chia-Jen Siao, Guhan Nagappan, Tina Marinic, Deqiang Jing, Kelly McGrath, Zhe-Yu Chen, Willie Mark, Lino Tessarollo, Francis S Lee, Bai Lu, Barbara L Hempstead.

Abstract

Pro-brain-derived neurotrophic factor (proBDNF) and mature BDNF utilize distinct receptors to mediate divergent neuronal actions. Using new tools to quantitate endogenous BDNF isoforms, we found that mouse neurons secrete both proBDNF and mature BDNF. The highest levels of proBDNF and p75 were observed perinatally and declined, but were still detectable, in adulthood. Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB.

Entities: Chemical Disease Gene Species

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Year: 2009 PMID： 19136973 PMCID： PMC2737352 DOI： 10.1038/nn.2244

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

13 in total

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2. Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF.

Authors: Tomoya Matsumoto; Stefanie Rauskolb; Martin Polack; Johannes Klose; Roland Kolbeck; Martin Korte; Yves-Alain Barde
Journal: Nat Neurosci Date: 2008-01-20 Impact factor: 24.884

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Journal: J Biol Chem Date: 2001-01-10 Impact factor: 5.157

5. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.

Authors: Henry K Teng; Kenneth K Teng; Ramee Lee; Saundrene Wright; Seema Tevar; Ramiro D Almeida; Pouneh Kermani; Risa Torkin; Zhe-Yu Chen; Francis S Lee; Rosemary T Kraemer; Anders Nykjaer; Barbara L Hempstead
Journal: J Neurosci Date: 2005-06-01 Impact factor: 6.167

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Authors: Zhe-Yu Chen; Alessandro Ieraci; Henry Teng; Henning Dall; Chui-Xiang Meng; Daniel G Herrera; Anders Nykjaer; Barbara L Hempstead; Francis S Lee
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7. The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity.

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8. Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 are sorted to dense-core vesicles and released via the regulated pathway in primary rat cortical neurons.

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Journal: J Neurosci Res Date: 2004-03-15 Impact factor: 4.164

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Journal: Nature Date: 1995-09-28 Impact factor: 49.962

10. Difference in trafficking of brain-derived neurotrophic factor between axons and dendrites of cortical neurons, revealed by live-cell imaging.

Authors: Naoki Adachi; Keigo Kohara; Tadaharu Tsumoto
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182 in total

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Journal: J Clin Exp Ophthalmol Date: 2015-10-25

3. p75 Neurotrophin Receptor Activation Regulates the Timing of the Maturation of Cortical Parvalbumin Interneuron Connectivity and Promotes Juvenile-like Plasticity in Adult Visual Cortex.

Authors: Elie Baho; Bidisha Chattopadhyaya; Marisol Lavertu-Jolin; Raffaele Mazziotti; Patricia N Awad; Pegah Chehrazi; Marianne Groleau; Celine Jahannault-Talignani; Elvire Vaucher; Fabrice Ango; Tommaso Pizzorusso; Laura Baroncelli; Graziella Di Cristo
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4. Differential Behavioral and Biochemical Responses to Caffeine in Male and Female Rats from a Validated Model of Attention Deficit and Hyperactivity Disorder.

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Journal: Mol Neurobiol Date: 2018-03-20 Impact factor: 5.590

5. Single-nucleotide polymorphisms in TrkB and risk for depression: findings from the women's interagency HIV study.

Authors: Valeriya Avdoshina; Italo Mocchetti; Chenglong Liu; Mary A Young; Kathryn Anastos; Mardge Cohen; Howard Crystal; Celeste L Pearce; Elizabeth T Golub; Rochelle E Tractenberg
Journal: J Acquir Immune Defic Syndr Date: 2013-10-01 Impact factor: 3.731

6. Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring.

Authors: Gurdeep Marwarha; Kate Claycombe-Larson; Jared Schommer; Othman Ghribi
Journal: J Nutr Biochem Date: 2017-04-06 Impact factor: 6.048