Literature DB >> 18204444

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF.

Tomoya Matsumoto1, Stefanie Rauskolb, Martin Polack, Johannes Klose, Roland Kolbeck, Martin Korte, Yves-Alain Barde.   

Abstract

Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input.

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Year:  2008        PMID： 18204444     DOI： 10.1038/nn2038

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  146 in total

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Review 4.  Progesterone, brain-derived neurotrophic factor and neuroprotection.

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7.  Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system.

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Review 8.  Neurotrophin regulation of neural circuit development and function.

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9.  Control of extracellular cleavage of ProBDNF by high frequency neuronal activity.

Authors:  Guhan Nagappan; Eugene Zaitsev; Vladimir V Senatorov; Jianmin Yang; Barbara L Hempstead; Bai Lu
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-15       Impact factor: 11.205

10.  The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism.

Authors:  Ozlem Bozdagi; Erin Rich; Sophie Tronel; Masato Sadahiro; Kamara Patterson; Matthew L Shapiro; Cristina M Alberini; George W Huntley; Stephen R J Salton
Journal:  J Neurosci       Date:  2008-09-24       Impact factor: 6.167
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