Literature DB >> 19130624

Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains.

J S Bailey1, L Grabowski-Boase, B M Steffy, T Wiltshire, G A Churchill, L M Tarantino.   

Abstract

We carried out a quantitative trait loci (QTL) mapping experiment in two phenotypically similar inbred mouse strains, C57BL/6J and C58/J, using the open-field assay, a well-established model of anxiety-related behavior in rodents. This intercross was initially carried out as a control cross for an ethylnitrosurea mutagenesis mapping study. Surprisingly, although open-field behavior is similar in the two strains, we identified significant QTL in their F2 progeny. Marker regression identified a locus on Chr 8 having associations with multiple open-field measures and a significant interaction between loci on Chr 13 and 17. Together, the Chr 8 locus and the interaction effect form the core set of QTL controlling these behaviors with additional loci on Chr 1 and 6 present in a subset of the behaviors.

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Year:  2008        PMID： 19130624      PMCID： PMC2888940          DOI： 10.1111/j.1601-183x.2008.00415.x

Source DB:  PubMed          Journal:  Genes Brain Behav        ISSN： 1601-183X            Impact factor:   3.449


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