| Literature DB >> 19363126 |
Frank W Albert1, Orjan Carlborg, Irina Plyusnina, Francois Besnier, Daniela Hedwig, Susann Lautenschläger, Doreen Lorenz, Jenny McIntosh, Christof Neumann, Henning Richter, Claudia Zeising, Rimma Kozhemyakina, Olesya Shchepina, Jürgen Kratzsch, Lyudmila Trut, Daniel Teupser, Joachim Thiery, Torsten Schöneberg, Leif Andersson, Svante Pääbo.
Abstract
A common feature of domestic animals is tameness-i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied an intercross between two lines of rats (Rattus norvegicus) selected over >60 generations for increased tameness and increased aggression against humans, respectively. We measured 45 traits, including tameness and aggression, anxiety-related traits, organ weights, and levels of serum components in >700 rats from an intercross population. Using 201 genetic markers, we identified two significant quantitative trait loci (QTL) for tameness. These loci overlap with QTL for adrenal gland weight and for anxiety-related traits and are part of a five-locus epistatic network influencing tameness. An additional QTL influences the occurrence of white coat spots, but shows no significant effect on tameness. The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general.Entities:
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Year: 2009 PMID： 19363126 PMCID： PMC2691762 DOI： 10.1534/genetics.109.102186
Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562