| Literature DB >> 19117546 |
Joshua Tam1, Dai Fukumura, Rakesh K Jain.
Abstract
We have developed a physiologically based mathematical model, with parameters derived from published experimental data, to simulate the regulatory effects of the leptin pathway on murine energy homeostasis. Model outcomes are consistent with data reported in the literature and reproduce key characteristics of the energy regulatory system, including compensatory responses that counteract changes in body weight and the failure of this ability when the leptin pathway is disrupted. Our model revealed the possibility of multiple steady states for body weight. It also provided a unified theoretical framework for two historically antagonistic hypotheses regarding body weight regulation ("set-point" versus "settling point"). Finally, our model has identified potential avenues for future investigations.Entities:
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Year: 2009 PMID： 19117546 PMCID： PMC2643084 DOI： 10.1016/j.cmet.2008.11.005
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287