Literature DB >> 19116

A potent new beta2-adrenoceptor blocking agent.

J L Imbs, F Miesch, J Schwartz, J Velly, G Leclerc, A Mann, C G Wermuth.   

Abstract

1 (t-Butyl-amino-3-ol-2-propyl) oximino-9 fluorene is a new beta2-adrenoceptor blocking agent with a pA2 of 9.23+/-0.25 on isolated trachea. 2 It provokes hypertension in normotensive rats and does not prevent arterial hypertension in SHR rats, although it does prevent the renin secretion normally induced by isoprenaline infusion.

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Year:  1977        PMID： 19116      PMCID： PMC1667284          DOI： 10.1111/j.1476-5381.1977.tb07508.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  beta-blocking drugs and renin secretion in the anaesthetized dog.

Authors:  J L Imbs; J Kraetz; M Schmidt; E Desaulles; J Schwartz
Journal:  Clin Sci Mol Med Suppl       Date:  1975-06

2.  The actions of selective beta-receptor antagonists on the guinea pig trachea.

Authors:  B Levy; B E Wilkenfeld
Journal:  Eur J Pharmacol       Date:  1970-07-01       Impact factor: 4.432

3.  Analysis of beta receptor drug interactions in isolated rabbit atrium, aorta, stomach and trachea.

Authors:  M Bristow; T R Sherrod; R D Green
Journal:  J Pharmacol Exp Ther       Date:  1970-01       Impact factor: 4.030

4.  Pressor effect of beta blocking agents in rats.

Authors:  D Regoli; U Regoli; E Gysling
Journal:  Can J Physiol Pharmacol       Date:  1972-03       Impact factor: 2.273

5.  A critical evaluation of three methods for the study of adrenergic beta-blocking and anti-arrhythmic agents.

Authors:  B Vargaftig; J L Coignet
Journal:  Eur J Pharmacol       Date:  1969-04       Impact factor: 4.432

6.  [Modified method for the testing of surface anesthesia on the rabbit cornea, using cocaine, procaine, propranolol, alprenolol, INPEA and verapamil].

Authors:  W Bartsch; K W Knopf
Journal:  Arzneimittelforschung       Date:  1970-08

7.  Comparison of beta-adrenergic blocking activities of propranolol, isopropylmethoxamine, sotalol, practolol, alprenolol, pindolol, oxprenolol and D-32 in the atria and trachea of the guinea-pig.

Authors:  D Horii; T Kawada; K Takeda; S Imai
Journal:  Arzneimittelforschung       Date:  1974-09

8.  Effects of prolonged treatment with adrenergic beta-receptor antagonists on blood pressure, cardiovascular design and reactivity in spontaneously hypertensive rats (SHR).

Authors:  L Weiss; Y Lundgren; B Folkow
Journal:  Acta Physiol Scand       Date:  1974-08

9.  Dopamine-induced neurogenic vasodilatation in isolated perfused muscle preparation of the dog.

Authors:  J L Willems; M G Bogaert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000
  9 in total
  15 in total

1.  Evidence for the participation of beta1-adrenoceptors in isoprenaline-induced renin release from rat kidny slices in vitro.

Authors:  E Desaulles; F Miesch; J Schwartz
Journal:  Br J Pharmacol       Date:  1978-07       Impact factor: 8.739

2.  Presynaptic beta-adrenoceptors in rat atria: evidence for the presence of stereoselective beta 1-adrenoceptors.

Authors:  M Heimburger; M J Montero; V Fougeres; F Beslot; M Davy; M Midol-Monnet; Y Cohen
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

3.  Analysis of the beta-receptor mediated effect on fast-contracting skeletal muscle in vitro.

Authors:  E Holmberg; B Waldeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-12       Impact factor: 3.000

4.  The role of beta 2-adrenoceptors in the IOP-lowering effect of adrenaline.

Authors:  H C Innemee; P A van Zwieten
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1982       Impact factor: 3.117

5.  Effects of a potent and specific beta 2-adrenoceptor antagonist on intraocular pressure.

Authors:  J A Nathanson
Journal:  Br J Pharmacol       Date:  1981-05       Impact factor: 8.739

6.  Effects of a beta 1-selective adrenergic agonist in normal human volunteers.

Authors:  K A Meurer; R Lang; V Hombach; A Helber
Journal:  Klin Wochenschr       Date:  1980-04-15

7.  Adrenergic regulation of intraocular pressure: identification of beta 2-adrenergic-stimulated adenylate cyclase in ciliary process epithelium.

Authors:  J A Nathanson
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

8.  The importance of choice of agonist in studies designed to predict beta 2 : beta 1 adrenoceptor selectivity of antagonists from pA2 values on guinea-pig trachea and atria.

Authors:  S R O'Donnell; J C Wanstall
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-09       Impact factor: 3.000

9.  Duration and selectivity in beta-adrenoceptor blocking action of a beta-adrenoceptor blocking drug, D-32 in conscious dogs.

Authors:  N Himori; S Honma; A Izumi; T Ishimori
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-02       Impact factor: 3.000

10.  Beta-adrenergic receptor subtypes in iris-ciliary body of rabbits.

Authors:  C J Schmitt; D M Gross; N N Share
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1984       Impact factor: 3.117
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