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Literature DB >> 6104743

Effects of a beta 1-selective adrenergic agonist in normal human volunteers.

K A Meurer, R Lang, V Hombach, A Helber.

Abstract

In healthy volunteers, the effects of prenalterol, a new beta 1-adrenoceptor agonist, on renal hemodynamics, excretory function, plasma-renin-activity, plasma cAMP concentration, and plasma and urinary norepinephrine were studied. Besides an increase in blood pressure, which was adjusted to about 20 mmHg above the resting values, and an increase of heart rate, prenalterol induced only transient decreases of urinary volume and free water clearance and in increase of sodium excretion. The other parameters measured did not change. Thus prenalterol mainly exerts positive inotropic and chronotropic effects and does not affect renal circulation.

Entities: Chemical Gene Species

Mesh：

Substances：
Adrenergic beta-Agonists

Year: 1980 PMID： 6104743 DOI： 10.1007/bf01477508

Source DB: PubMed Journal: Klin Wochenschr ISSN： 0023-2173

15 in total

1. A potent new beta2-adrenoceptor blocking agent.

Authors: J L Imbs; F Miesch; J Schwartz; J Velly; G Leclerc; A Mann; C G Wermuth
Journal: Br J Pharmacol Date: 1977-07 Impact factor: 8.739

2. The beta-adrenoceptor controlling renin release.

Authors: H F Oates; L M Stoker; J C Monaghan; G S Stokes
Journal: Arch Int Pharmacodyn Ther Date: 1978-08

3. [Participation of beta 1- and beta 2-adrenergic receptors on the renin-liberation].

Authors: K A Meurer; L Maxrath; A Helber; W Kaufmann
Journal: Verh Dtsch Ges Inn Med Date: 1976

4. A photometric method for the determination of insulin in plasma and urine.

Authors: J H ROE; J H EPSTEIN; N P GOLDSTEIN
Journal: J Biol Chem Date: 1949-04 Impact factor: 5.157

5. [Hemodynamic and humoral changes during administration of a sympathomimetic and a sympatholytic drug with special notes on the regulation of renin release (author's transl)].

Authors: K A Meurer; H Geuchen; R Lang; W Kaufmann
Journal: Klin Wochenschr Date: 1979-04-01

6. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects.

Authors: E Haber; T Koerner; L B Page; B Kliman; A Purnode
Journal: J Clin Endocrinol Metab Date: 1969-10 Impact factor: 5.958

Effects of a beta 1-selective adrenergic agonist in normal human volunteers.

1. A potent new beta2-adrenoceptor blocking agent.

2. The beta-adrenoceptor controlling renin release.

3. [Participation of beta 1- and beta 2-adrenergic receptors on the renin-liberation].

4. A photometric method for the determination of insulin in plasma and urine.

5. [Hemodynamic and humoral changes during administration of a sympathomimetic and a sympatholytic drug with special notes on the regulation of renin release (author's transl)].

6. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects.

7. Fluorimetric determination of plasma catecholamines: normal human epinephrine and norepinephrine levels.

8. Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs.

9. Cardiovascular effects of prenalterol (H133/22) in normal man.

10. Radioimmunoassay for the measurement of adenosine 3',5'-cyclic phosphate.

1. Metabolic and hormonal effects of preferential beta 1 and beta 2-adrenoceptor stimulation in man.

2. Effects of beta 1-adrenoceptor agonism on plasma renin activity in normal men.