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Literature DB >> 6116512

Effects of a potent and specific beta 2-adrenoceptor antagonist on intraocular pressure.

Abstract

1 Physiological studies support the possibility of adrenergic regulation of aqueous humor secretion from the ciliary process, a tissue which has recently been shown to contain a predominance of beta 2-adrenoceptors. 2 The present experiments examine the effects of a potent and highly specific beta 2-antagonist (IPS 339) on intraocular pressure in the normal rabbit eye. 3 The observed decrease in pressure caused by IPS 339 suggests that highly specific beta 2-antagonists may be useful in decreasing elevated intraocular pressure.

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Year: 1981 PMID： 6116512 PMCID： PMC2071848 DOI： 10.1111/j.1476-5381.1981.tb16776.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

14 in total

6. ICI 118,551: an effective ocular hypotensive agent with selectivity for the ciliary process beta 2-adrenoceptor and with minimal cardiac side effects.

Authors: J A Nathanson
Journal: Br J Pharmacol Date: 1984-11 Impact factor: 8.739

6 in total

Effects of a potent and specific beta 2-adrenoceptor antagonist on intraocular pressure.

1. A potent new beta2-adrenoceptor blocking agent.

2. In vitro determination of the ability of drugs to bind to adrenergic receptors.

3. The pharmacological specificity of beta-1 and beta-2 adrenergic receptors in rat heart and lung in vitro.

Review 4. The beta-adrenergic blocking agents and the treatment of glaucoma.

5. Adrenergic drugs and intraocular pressure: effects of selective beta-adrenergic agonists.

6. Some characteristics of an adenyl cyclase preparation from rabbit ciliary process tissue.

7. Beta-adrenergic responses in the eyes of rabbits, primates, and man.

8. Drug therapy of glaucoma.

9. Effects of catecholamines on the ocular tension of normal and sympathetically denervated rabbit eyes.

Review 10. Experimental studies on the mechanism of action of timolol.

1. Neodymium-YAG transscleral cyclocoagulation in rabbit eyes.

2. beta-Adrenergic receptor subtypes and intraocular pressure.

3. The role of beta 2-adrenoceptors in the IOP-lowering effect of adrenaline.

4. Beta adrenergic receptors in pigmented ciliary processes.

5. Beta-adrenergic receptor subtypes in iris-ciliary body of rabbits.

6. ICI 118,551: an effective ocular hypotensive agent with selectivity for the ciliary process beta 2-adrenoceptor and with minimal cardiac side effects.