PURPOSE OF INVESTIGATION: To evaluate the effect of tamoxifen on mammographic density using a qualitative and a semiquantitative method. METHODS: Mammograms from 148 women treated for breast cancer before and after surgery were reviewed: 68 were administered tamoxifen; 80 did not receive tamoxifen. The mammograms were classified in one of the four BIRADS density categories by two radiologists blinded to the treatment and by a computer-assisted method after digitizing images. RESULTS: At mammographic one-year-follow-up density was reduced in both groups and remained stable in the following years. A comparison of mammograms performed before surgery and after one year showed a statistically significant difference in density reduction between the tamoxifen and the non-tamoxifen-treated group. Good agreement was obtained between the qualitative and semiquantitative method. CONCLUSION: Breast density reduction observed in women treated with tamoxifen may help in the detection of small tumors in dense breasts by means of reducing the masking effect of parenchyma.
PURPOSE OF INVESTIGATION: To evaluate the effect of tamoxifen on mammographic density using a qualitative and a semiquantitative method. METHODS: Mammograms from 148 women treated for breast cancer before and after surgery were reviewed: 68 were administered tamoxifen; 80 did not receive tamoxifen. The mammograms were classified in one of the four BIRADS density categories by two radiologists blinded to the treatment and by a computer-assisted method after digitizing images. RESULTS: At mammographic one-year-follow-up density was reduced in both groups and remained stable in the following years. A comparison of mammograms performed before surgery and after one year showed a statistically significant difference in density reduction between the tamoxifen and the non-tamoxifen-treated group. Good agreement was obtained between the qualitative and semiquantitative method. CONCLUSION: Breast density reduction observed in women treated with tamoxifen may help in the detection of small tumors in dense breasts by means of reducing the masking effect of parenchyma.
Authors: Sarah J Nyante; Mark E Sherman; Ruth M Pfeiffer; Amy Berrington de Gonzalez; Louise A Brinton; Erin J Aiello Bowles; Robert N Hoover; Andrew Glass; Gretchen L Gierach Journal: J Natl Cancer Inst Date: 2015-02-06 Impact factor: 13.506
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Authors: Hamed Samavat; Giske Ursin; Tim H Emory; Eunjung Lee; Renwei Wang; Carolyn J Torkelson; Allison M Dostal; Karen Swenson; Chap T Le; Chung S Yang; Mimi C Yu; Douglas Yee; Anna H Wu; Jian-Min Yuan; Mindy S Kurzer Journal: Cancer Prev Res (Phila) Date: 2017-09-13
Authors: Sarah J Nyante; Mark E Sherman; Ruth M Pfeiffer; Amy Berrington de Gonzalez; Louise A Brinton; Erin J Aiello Bowles; Robert N Hoover; Andrew Glass; Gretchen L Gierach Journal: Cancer Epidemiol Biomarkers Prev Date: 2015-11-06 Impact factor: 4.254