Literature DB >> 17964803

Clinical strategies to enhance T cell reconstitution.

Gabrielle L Goldberg1, Johannes L Zakrzewski, Miguel A Perales, Marcel R M van den Brink.   

Abstract

Strategies to enhance T cell recovery are of increasing clinical importance to overcome long lasting T cell deficiencies, which occur in association with infections, autoimmunity and chemo/radiotherapy as well as aging of the immune system. In this review we discuss those strategies that are close to or in the clinic. Interleukin-7, sex steroid modulation, keratinocyte growth factor, growth hormone and cellular therapies using ex vivo generated T-cell precursors are currently being tested in recipients of a hematopoietic stem cell transplantation and patients with malignancies or HIV/AIDS.

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Year:  2007        PMID： 17964803      PMCID： PMC2696308          DOI： 10.1016/j.smim.2007.08.001

Source DB:  PubMed          Journal:  Semin Immunol        ISSN： 1044-5323            Impact factor:   11.130


  127 in total

Review 1.  Palifermin (Kepivance) for the treatment of oral mucositis in patients with hematologic malignancies requiring hematopoietic stem cell support.

Authors:  Michelle L Radtke; Jill M Kolesar
Journal:  J Oncol Pharm Pract       Date:  2005-09       Impact factor: 1.809

2.  Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation.

Authors:  Johannes L Zakrzewski; Adam A Kochman; Sydney X Lu; Theis H Terwey; Theo D Kim; Vanessa M Hubbard; Stephanie J Muriglan; David Suh; Odette M Smith; Jeremy Grubin; Neel Patel; Andrew Chow; Javier Cabrera-Perez; Radhika Radhakrishnan; Adi Diab; Miguel-Angel Perales; Gabrielle Rizzuto; Ewa Menet; Eric G Pamer; Glen Heller; Juan Carlos Zúñiga-Pflücker; Onder Alpdogan; Marcel R M van den Brink
Journal:  Nat Med       Date:  2006-08-27       Impact factor: 53.440

3.  Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration.

Authors:  Onder Alpdogan; Vanessa M Hubbard; Odette M Smith; Neel Patel; Sydney Lu; Gabrielle L Goldberg; Daniel H Gray; Jared Feinman; Adam A Kochman; Jeffrey M Eng; David Suh; Stephanie J Muriglan; Richard L Boyd; Marcel R M van den Brink
Journal:  Blood       Date:  2005-11-22       Impact factor: 22.113

4.  Factors associated with early molecular remission after T cell-depleted allogeneic stem cell transplantation for chronic myelogenous leukemia.

Authors:  Bipin N Savani; Katayoun Rezvani; Stephan Mielke; Aldemar Montero; Roger Kurlander; Charles S Carter; Susan Leitman; Elizabeth J Read; Richard Childs; A John Barrett
Journal:  Blood       Date:  2005-08-30       Impact factor: 22.113

5.  Successful immune reconstitution decreases leukemic relapse and improves survival in recipients of unrelated cord blood transplantation.

Authors:  Robertson Parkman; Geoff Cohen; Shelly L Carter; Kenneth I Weinberg; Bernadette Masinsin; Eva Guinan; Joanne Kurtzberg; John E Wagner; Nancy A Kernan
Journal:  Biol Blood Marrow Transplant       Date:  2006-09       Impact factor: 5.742

6.  IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells.

Authors:  Steven A Rosenberg; Claude Sportès; Mojgan Ahmadzadeh; Terry J Fry; Lien T Ngo; Susan L Schwarz; Maryalice Stetler-Stevenson; Kathleen E Morton; Sharon A Mavroukakis; Michel Morre; Renaud Buffet; Crystal L Mackall; Ronald E Gress
Journal:  J Immunother       Date:  2006 May-Jun       Impact factor: 4.456

7.  Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice.

Authors:  Benny J Chen; Xiuyu Cui; Gregory D Sempowski; Nelson J Chao
Journal:  Exp Hematol       Date:  2003-10       Impact factor: 3.084

8.  Early lymphocyte recovery after autologous stem cell transplantation predicts superior survival in mantle-cell lymphoma.

Authors:  C Joao; L F Porrata; D J Inwards; S M Ansell; I N Micallef; P B Johnston; D A Gastineau; S N Markovic
Journal:  Bone Marrow Transplant       Date:  2006-05       Impact factor: 5.483

9.  Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

Authors:  Susan M Kaech; Joyce T Tan; E John Wherry; Bogumila T Konieczny; Charles D Surh; Rafi Ahmed
Journal:  Nat Immunol       Date:  2003-11-16       Impact factor: 25.606

10.  IL-7 promotes the transition of CD4 effectors to persistent memory cells.

Authors:  JiChu Li; Gail Huston; Susan L Swain
Journal:  J Exp Med       Date:  2003-12-15       Impact factor: 14.307
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  29 in total

1.  Immune aging and challenges for immune protection of the graying population.

Authors:  Abbe N Vallejo
Journal:  Aging Dis       Date:  2011-10-28       Impact factor: 6.745

Review 2.  Aging and immune function: molecular mechanisms to interventions.

Authors:  Subramaniam Ponnappan; Usha Ponnappan
Journal:  Antioxid Redox Signal       Date:  2011-01-08       Impact factor: 8.401

Review 3.  The ageing immune system: is it ever too old to become young again?

Authors:  Kenneth Dorshkind; Encarnacion Montecino-Rodriguez; Robert A J Signer
Journal:  Nat Rev Immunol       Date:  2009-01       Impact factor: 53.106

Review 4.  Thymic rejuvenation and aging.

Authors:  Melissa S Ventevogel; Gregory D Sempowski
Journal:  Curr Opin Immunol       Date:  2013-07-04       Impact factor: 7.486

5.  Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy.

Authors:  Lili Cheng; Jianfei Guo; Liguang Sun; Jian Fu; Peter F Barnes; Daniel Metzger; Pierre Chambon; Robert G Oshima; Takashi Amagai; Dong-Ming Su
Journal:  J Biol Chem       Date:  2009-12-02       Impact factor: 5.157

6.  Umbilical cord-derived mesenchymal stem cells regulate thymic epithelial cell development and function in Foxn1(-/-) mice.

Authors:  Guangyang Liu; Lihua Wang; Tianxiang Pang; Delin Zhu; Yi Xu; Hanyu Wang; Xiuli Cong; Yongjun Liu
Journal:  Cell Mol Immunol       Date:  2014-02-24       Impact factor: 11.530

7.  Human proT-cells generated in vitro facilitate hematopoietic stem cell-derived T-lymphopoiesis in vivo and restore thymic architecture.

Authors:  Génève Awong; Jastaranpreet Singh; Mahmood Mohtashami; Maria Malm; Ross N La Motte-Mohs; Patricia M Benveniste; Pablo Serra; Elaine Herer; Marcel R van den Brink; Juan Carlos Zúñiga-Pflücker
Journal:  Blood       Date:  2013-11-08       Impact factor: 22.113

8.  Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers.

Authors:  N Anandasabapathy; G Breton; A Hurley; M Caskey; C Trumpfheller; P Sarma; J Pring; M Pack; N Buckley; I Matei; D Lyden; J Green; T Hawthorne; H C Marsh; M Yellin; T Davis; T Keler; S J Schlesinger
Journal:  Bone Marrow Transplant       Date:  2015-04-27       Impact factor: 5.483

9.  Igf-I stimulates in vivo thymopoiesis after stem cell transplantation in a child with Omenn syndrome.

Authors:  Nina S Ma; Ami J Shah; Mitchell E Geffner; Neena Kapoor
Journal:  J Clin Immunol       Date:  2009-09-24       Impact factor: 8.317

Review 10.  Rejuvenation of the aging T cell compartment.

Authors:  Amanda M Holland; Marcel R M van den Brink
Journal:  Curr Opin Immunol       Date:  2009-07-14       Impact factor: 7.486
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