Literature DB >> 18756247

Puzzles, promises and a cure for ageing.

Jan Vijg1, Judith Campisi.   

Abstract

Recent discoveries in the science of ageing indicate that lifespan in model organisms such as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional or pharmacological intervention. A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect.

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Year:  2008        PMID： 18756247      PMCID： PMC2774752          DOI： 10.1038/nature07216

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  71 in total

1.  Extension of life-span with superoxide dismutase/catalase mimetics.

Authors:  S Melov; J Ravenscroft; S Malik; M S Gill; D W Walker; P E Clayton; D C Wallace; B Malfroy; S R Doctrow; G J Lithgow
Journal:  Science       Date:  2000-09-01       Impact factor: 47.728

2.  Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles.

Authors:  Carl E G Bruder; Arkadiusz Piotrowski; Antoinet A C J Gijsbers; Robin Andersson; Stephen Erickson; Teresita Diaz de Ståhl; Uwe Menzel; Johanna Sandgren; Desiree von Tell; Andrzej Poplawski; Michael Crowley; Chiquito Crasto; E Christopher Partridge; Hemant Tiwari; David B Allison; Jan Komorowski; Gert-Jan B van Ommen; Dorret I Boomsma; Nancy L Pedersen; Johan T den Dunnen; Karin Wirdefeldt; Jan P Dumanski
Journal:  Am J Hum Genet       Date:  2008-02-14       Impact factor: 11.025

3.  A systematic look at an old problem.

Authors:  Thomas B L Kirkwood
Journal:  Nature       Date:  2008-02-07       Impact factor: 49.962

4.  A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys.

Authors:  P V Vaitkevicius; M Lane; H Spurgeon; D K Ingram; G S Roth; J J Egan; S Vasan; D R Wagle; P Ulrich; M Brines; J P Wuerth; A Cerami; E G Lakatta
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-30       Impact factor: 11.205

Review 5.  Protein glycation, diabetes, and aging.

Authors:  P Ulrich; A Cerami
Journal:  Recent Prog Horm Res       Date:  2001

6.  Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging.

Authors:  A Krtolica; S Parrinello; S Lockett; P Y Desprez; J Campisi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-02       Impact factor: 11.205

7.  Remarkable longevity and stress resistance of nematode PI3K-null mutants.

Authors:  Srinivas Ayyadevara; Ramani Alla; John J Thaden; Robert J Shmookler Reis
Journal:  Aging Cell       Date:  2007-11-07       Impact factor: 9.304

8.  Cancer suppression at old age.

Authors:  Charles Harding; Francesco Pompei; Ellen E Lee; Richard Wilson
Journal:  Cancer Res       Date:  2008-06-01       Impact factor: 12.701

9.  Functionally significant insulin-like growth factor I receptor mutations in centenarians.

Authors:  Yousin Suh; Gil Atzmon; Mi-Ook Cho; David Hwang; Bingrong Liu; Daniel J Leahy; Nir Barzilai; Pinchas Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-03       Impact factor: 11.205

10.  Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.

Authors:  Colin Selman; Steven Lingard; Agharul I Choudhury; Rachel L Batterham; Marc Claret; Melanie Clements; Faruk Ramadani; Klaus Okkenhaug; Eugene Schuster; Eric Blanc; Matthew D Piper; Hind Al-Qassab; John R Speakman; Danielle Carmignac; Iain C A Robinson; Janet M Thornton; David Gems; Linda Partridge; Dominic J Withers
Journal:  FASEB J       Date:  2007-10-10       Impact factor: 5.191
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  158 in total

1.  DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function.

Authors:  Ling-Yang Hao; Benoit I Giasson; Nancy M Bonini
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-10       Impact factor: 11.205

2.  20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans.

Authors:  Niki Chondrogianni; Konstantina Georgila; Nikos Kourtis; Nektarios Tavernarakis; Efstathios S Gonos
Journal:  FASEB J       Date:  2014-11-13       Impact factor: 5.191

3.  Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans.

Authors:  Roongpetch Keowkase; Marwa Aboukhatwa; Yuan Luo
Journal:  Neuropharmacology       Date:  2010-04-24       Impact factor: 5.250

Review 4.  Assessing cell and organ senescence biomarkers.

Authors:  Bruno Bernardes de Jesus; Maria A Blasco
Journal:  Circ Res       Date:  2012-06-22       Impact factor: 17.367

5.  APOE ϵ4, rated life experiences, and affect among centenarians.

Authors:  Peter Martin; S Michal Jazwinski; Adam Davey; Robert C Green; Maurice Macdonald; Jennifer A Margrett; Ilene C Siegler; Jonathan Arnold; John L Woodard; Mary Ann Johnson; Sangkyu Kim; Jianliang Dai; Li Li; Mark A Batzer; Leonard W Poon
Journal:  Aging Ment Health       Date:  2013-09-02       Impact factor: 3.658

6.  Curcumin protects dopaminergic neurons against inflammation-mediated damage and improves motor dysfunction induced by single intranigral lipopolysaccharide injection.

Authors:  Neha Sharma; Sheetal Sharma; Bimla Nehru
Journal:  Inflammopharmacology       Date:  2017-04-13       Impact factor: 4.473

Review 7.  Biochemical markers of aging for longitudinal studies in humans.

Authors:  Peter M Engelfriet; Eugène H J M Jansen; H Susan J Picavet; Martijn E T Dollé
Journal:  Epidemiol Rev       Date:  2013-02-04       Impact factor: 6.222

8.  Three different motor task strategies to assess neuromuscular adjustments during fatiguing muscle contractions in young and older men.

Authors:  Laura Kyguoliene; Albertas Skurvydas; Nerijus Eimantas; Neringa Baranauskiene; Rasa Steponaviciute; Laura Daniuseviciute; Henrikas Paulauskas; Margarita Cernych; Marius Brazaitis
Journal:  Exp Brain Res       Date:  2018-05-12       Impact factor: 1.972

Review 9.  "Boomerang Neuropathology" of Late-Onset Alzheimer's Disease is Shrouded in Harmful "BDDS": Breathing, Diet, Drinking, and Sleep During Aging.

Authors:  Mak Adam Daulatzai
Journal:  Neurotox Res       Date:  2015-04-25       Impact factor: 3.911

10.  Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress.

Authors:  Eleni N Tsakiri; Gerasimos P Sykiotis; Issidora S Papassideri; Vassilis G Gorgoulis; Dirk Bohmann; Ioannis P Trougakos
Journal:  FASEB J       Date:  2013-03-01       Impact factor: 5.191
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