Literature DB >> 19099510

Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells.

Susanna Cogoi1, Manikandan Paramasivam, Vyacheslav Filichev, Imrich Géci, Erik B Pedersen, Luigi E Xodo.   

Abstract

A new quadruplex motif located in the promoter of the human KRAS gene, within a nuclease hypersensitive element (NHE), has been characterized. Oligonucleotides mimicking this quadruplex are found to compete with a DNA-protein complex between NHE and a nuclear extract from pancreatic cancer cells. When modified with (R)-1-O-[4-1-(1-pyrenylethynyl) phenylmethyl]glycerol insertions (TINA), the quadruplex oligonucleotides showed a dramatic increase of the T(m) (deltaT(m) from 22 to 32 degrees C) and a strong antiproliferative effects in Panc-1 cells.

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Year:  2009        PMID： 19099510     DOI： 10.1021/jm800874t

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  29 in total

1.  High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation.

Authors:  Abdelaziz Kerkour; Julien Marquevielle; Stefaniia Ivashchenko; Liliya A Yatsunyk; Jean-Louis Mergny; Gilmar F Salgado
Journal:  J Biol Chem       Date:  2017-03-22       Impact factor: 5.157

2.  G-ruption: the third international meeting on G-quadruplex and G-assembly.

Authors:  Liliya A Yatsunyk; Tracy M Bryan; F Brad Johnson
Journal:  Biochimie       Date:  2012-09-10       Impact factor: 4.079

Review 3.  The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics.

Authors:  Tracy A Brooks; Laurence H Hurley
Journal:  Nat Rev Cancer       Date:  2009-11-12       Impact factor: 60.716

4.  Optimal design of parallel triplex forming oligonucleotides containing Twisted Intercalating Nucleic Acids--TINA.

Authors:  Uffe V Schneider; Nikolaj D Mikkelsen; Nina Jøhnk; Limei M Okkels; Henrik Westh; Gorm Lisby
Journal:  Nucleic Acids Res       Date:  2010-03-24       Impact factor: 16.971

5.  Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression.

Authors:  Christine E Kaiser; Natalie A Van Ert; Prashansa Agrawal; Reena Chawla; Danzhou Yang; Laurence H Hurley
Journal:  J Am Chem Soc       Date:  2017-06-15       Impact factor: 15.419

Review 6.  Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

Authors:  Shankar Balasubramanian; Laurence H Hurley; Stephen Neidle
Journal:  Nat Rev Drug Discov       Date:  2011-04       Impact factor: 84.694

7.  RNA G-Quadruplexes in the model plant species Arabidopsis thaliana: prevalence and possible functional roles.

Authors:  Melissa A Mullen; Kalee J Olson; Paul Dallaire; François Major; Sarah M Assmann; Philip C Bevilacqua
Journal:  Nucleic Acids Res       Date:  2010-09-21       Impact factor: 16.971

8.  Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids.

Authors:  Erik B Pedersen; Jakob T Nielsen; Claus Nielsen; Vyacheslav V Filichev
Journal:  Nucleic Acids Res       Date:  2010-11-09       Impact factor: 16.971

9.  Increasing the analytical sensitivity by oligonucleotides modified with para- and ortho-twisted intercalating nucleic acids--TINA.

Authors:  Uffe V Schneider; Imrich Géci; Nina Jøhnk; Nikolaj D Mikkelsen; Erik B Pedersen; Gorm Lisby
Journal:  PLoS One       Date:  2011-06-03       Impact factor: 3.240

10.  MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice.

Authors:  Susanna Cogoi; Sonia Zorzet; Valentina Rapozzi; Imrich Géci; Erik B Pedersen; Luigi E Xodo
Journal:  Nucleic Acids Res       Date:  2013-03-06       Impact factor: 16.971
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