Literature DB >> 19099089

Tracing the Pathogenesis of Type 1 Diabetes: A Report on the 44th Annual Meeting of the European Association for the Study of Diabetes (EASD).

Liang-Hao Guo1, Peter Achenbach.   

Abstract

Clinical type 1 diabetes is preceded by autoimmune destruction of the pancreatic beta-cells. However, progression to disease is not uniform. One challenge facing current diabetes research is therefore to identify biomarker profiles that accurately reflect the individual stage of type 1 diabetes pathogenesis and develop new techniques to distinguish between these profiles and associated diabetes risks. This report highlights some of the recent studies on diabetes biomarkers, with a particular focus on zinc transporter ZnT8, presented at the EASD meeting in September 2008 in Rome, Italy.

Entities:  

Year:  2008        PMID： 19099089      PMCID： PMC2613273          DOI： 10.1900/RDS.2008.5.171

Source DB:  PubMed          Journal:  Rev Diabet Stud        ISSN： 1613-6071


  9 in total

1.  A genome-wide association study identifies novel risk loci for type 2 diabetes.

Authors:  Robert Sladek; Ghislain Rocheleau; Johan Rung; Christian Dina; Lishuang Shen; David Serre; Philippe Boutin; Daniel Vincent; Alexandre Belisle; Samy Hadjadj; Beverley Balkau; Barbara Heude; Guillaume Charpentier; Thomas J Hudson; Alexandre Montpetit; Alexey V Pshezhetsky; Marc Prentki; Barry I Posner; David J Balding; David Meyre; Constantin Polychronakos; Philippe Froguel
Journal:  Nature       Date:  2007-02-11       Impact factor: 49.962

2.  In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion.

Authors:  Fabrice Chimienti; Séverine Devergnas; François Pattou; Frans Schuit; Rachel Garcia-Cuenca; Brigitte Vandewalle; Julie Kerr-Conte; Leentje Van Lommel; Didier Grunwald; Alain Favier; Michel Seve
Journal:  J Cell Sci       Date:  2006-09-19       Impact factor: 5.285

3.  Association analysis of type 2 diabetes Loci in type 1 diabetes.

Authors:  Hui-Qi Qu; Struan F A Grant; Jonathan P Bradfield; Cecilia Kim; Edward Frackelton; Hakon Hakonarson; Constantin Polychronakos
Journal:  Diabetes       Date:  2008-04-21       Impact factor: 9.461

4.  A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population.

Authors:  Caroline Brorsson; Regine Bergholdt; Marketa Sjögren; Stefanie Eising; Karina Meden Sørensen; David M Hougaard; Marju Orho-Melander; Leif Groop; Flemming Pociot
Journal:  Mol Genet Metab       Date:  2008-04-08       Impact factor: 4.797

5.  SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset.

Authors:  Henning Gohlke; Uta Ferrari; Kerstin Koczwara; Ezio Bonifacio; Thomas Illig; Anette-G Ziegler
Journal:  Rev Diabet Stud       Date:  2008-05-10

6.  The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes.

Authors:  Janet M Wenzlau; Kirstine Juhl; Liping Yu; Ong Moua; Suparna A Sarkar; Peter Gottlieb; Marian Rewers; George S Eisenbarth; Jan Jensen; Howard W Davidson; John C Hutton
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-17       Impact factor: 11.205

7.  Zinc transporter 8 antibodies complement GAD and IA-2 antibodies in the identification and characterization of adult-onset autoimmune diabetes: Non Insulin Requiring Autoimmune Diabetes (NIRAD) 4.

Authors:  Vito Lampasona; Antonio Petrone; Claudio Tiberti; Marco Capizzi; Marialuisa Spoletini; Sergio di Pietro; Marco Songini; Sara Bonicchio; Francesco Giorgino; Ezio Bonifacio; Emanuele Bosi; Raffaella Buzzetti
Journal:  Diabetes Care       Date:  2009-10-06       Impact factor: 19.112

8.  A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes.

Authors:  Janet M Wenzlau; Yu Liu; Liping Yu; Ong Moua; Kimberly T Fowler; Sampathkumar Rangasamy; Jay Walters; George S Eisenbarth; Howard W Davidson; John C Hutton
Journal:  Diabetes       Date:  2008-06-30       Impact factor: 9.461

9.  Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes.

Authors:  Matej Oresic; Satu Simell; Marko Sysi-Aho; Kirsti Näntö-Salonen; Tuulikki Seppänen-Laakso; Vilhelmiina Parikka; Mikko Katajamaa; Anne Hekkala; Ismo Mattila; Päivi Keskinen; Laxman Yetukuri; Arja Reinikainen; Jyrki Lähde; Tapani Suortti; Jari Hakalax; Tuula Simell; Heikki Hyöty; Riitta Veijola; Jorma Ilonen; Riitta Lahesmaa; Mikael Knip; Olli Simell
Journal:  J Exp Med       Date:  2008-12-15       Impact factor: 14.307
  9 in total

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